SIRT4 protects against intestinal fibrosis by facilitating GLS1 degradation

Xue, Xinru; Zeng, Xi; Wu, Xiaoqian; Mu, Kexin; Dai, Yue; Wei, Zhifeng

doi:10.1016/j.matbio.2023.08.001

Cited by 6 publications

(2 citation statements)

References 53 publications

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“…The decrease in SIRT4 is negatively associated with disease severity. 29 Furthermore, according to classical cognition, chronic inflammation and fibrosis in the intestine are closely linked. Cytokines, including interleukins, contribute to the formation of fibrosis.…”

Section: Molecular Pathways In Fibrosismentioning

confidence: 99%

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Intestinal strictures in Crohn's disease: An update from 2023

Liu,

Huang,

Wang

et al. 2024

UEG Journal

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Crohn's disease (CD) is a chronic inflammatory disease that leads to intestinal stricture in nearly 35% of cases within 10 years of initial diagnosis. The unknown pathogenesis, lack of universally accepted criteria, and absence of an effective management approach remain unconquered challenges in structuring CD. The pathogenesis of stricturing CD involves intricate interactions between factors such as immune cell dysbiosis, fibroblast activation, and microecology imbalance. New techniques such as single‐cell sequencing provide a fresh perspective. Non‐invasive diagnostic tools such as serum biomarkers and novel cross‐sectional imaging techniques offer a precise understanding of intestinal fibrostenosis. Here, we provide a timely and comprehensive review of the worthy advancements in intestinal strictures in 2023, aiming to dispense cutting‐edge information regarding fibrosis and to build a cornerstone for researchers and clinicians to make greater progress in the field of intestinal strictures.

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Section: Molecular Pathways In Fibrosismentioning

confidence: 99%

“…SIRI4 hinders SIRT5's stabilizing interaction with glutaminase 1, therefore impeding ECM deposition by inhibiting glutaminolysis. The decrease in SIRT4 is negatively associated with disease severity 29 …”

Section: Mechanismmentioning

confidence: 99%