SIRTI and cortisol in unexplained infertile females; a cross sectional study, in Karachi Pakistan

Alam, Faiza; Khan, Taseer Ahmed; Ali, Rabiya; Tariq, Fizza; Rehman, Rehana

doi:10.1016/j.tjog.2020.01.004

Cited by 10 publications

(18 citation statements)

References 40 publications

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“…This finding is supported by another study conducted by our group which revealed that decreased levels of SIRT1 in presence of low levels of cortisol may indirectly affects the HPA axis further disturbing the regulation and production of steroid hormones, maturation of oocyte along with maintenance and regression of the corpora lutea 43 …”

Section: Discussionsupporting

confidence: 76%

Suggested role of silent information regulator 1 (SIRT1) gene in female infertility: A cross‐sectional study in Pakistan

Alam

Rehman

Fatima

et al. 2021

Int J Clinical Practice

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Aim & Objective Silent information regulator 1 (SIRT1) gene stimulates the expression of antioxidants and repairs damaged cells. It affects the mitochondrial activity within the oocytes to overcome the oxidant stress. We aimed to assess an association of SIRT1 polymorphism (Tag SNPs rs10509291 and rs12778366) with fertility, and assess serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), oestradiol, progesterone, manganese superoxide (MnSOD) and SIRT1. Material and Methods In this cross‐sectional study, 207 fertile and 135 infertile subjects between the ages of 18‐45 years were recruited. Polymerase chain reaction (PCR) was performed; products were electrophoresed in a 2% agarose gel. Descriptive analysis of continuous variables was expressed as mean ± standard deviation. Mann‐Whitney test was performed for comparison of groups, P value <.001 was considered significant. Single Nucleotide Polymorphism (SNP) data were analysed by applying chi‐squared statistics. Results All subjects were age matched (P = .896). SIRT1 levels were significantly lower in infertile females when compared with fertile subjects (P < .001). AA (rs10509291) and CC (rs12778366) variant frequency was higher in the infertile than fertile subjects (P < .01). Similarly, the frequency of A allele (rs10509291) and C allele (rs12778366) was higher in infertile subjects (P < .001). Infertile females (29%) showed existence of SNP rs10509291 while 49% demonstrated genetic variation of rs12778366. MnSOD and SIRT1 levels were found to be lower in these subjects. Conclusion The presence of SIRT1 genetic variants (rs10509291 and rs12778366) apparently disturbs the expression of SIRT1 deteriorating mitochondrial antioxidant function within the oocytes, instigating oxidative stress within. Their probable effect on modulating oocyte maturation may be the cause of infertility in females.

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Section: Discussionsupporting

confidence: 76%

Suggested role of silent information regulator 1 (SIRT1) gene in female infertility: A cross‐sectional study in Pakistan

Alam

Rehman

Fatima

et al. 2021

Int J Clinical Practice

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“…Excess ROS may lead to cell cycle arrest and apoptosis in follicular oocytes. They may affect not only ovarian but also uterine function, resulting in decreased fertilization and pregnancy rates [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility

Didziokaite

Biliute

Gudaite

et al. 2023

IJMS

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Oxidative stress (OS) plays an important role in a variety of physiological and pathological processes of the female reproductive system. In recent years the relationship between OS and endometriosis has been of particular interest, and a theory has been suggested that OS may be a cause of endometriosis development. While the link between endometriosis and infertility is well established, minimal or mild stages of endometriosis are not considered to cause infertility. Increasing evidence of OS as a leading agent in the development of endometriosis has brought up a theory of minimal/mild endometriosis itself being one of the manifestations of high OS rather than a separate disease which directly causes infertility. Moreover, further development of the disease is thought to contribute to an increased production of reactive oxygen species (ROS) thus leading to the progression of endometriosis itself as well as to other pathological processes in the female reproductive system. Therefore, in case of minimal or mild endometriosis, the less invasive treatment could be offered in order to stop the ongoing cycle of endometriosis-reinforced excess ROS production and to reduce their harmful effects. In this article the existing connection between OS, endometriosis, and infertility is explored.

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“…In addition to the important role that chaperones play in the regulation of proteostasis in the male germline, the contribution of sirtuin proteins to fertility has also received increasing attention in recent years (Bell et al, 2014;Rato et al, 2016;Liu et al, 2017;Tatone et al, 2018;Zhang et al, 2019;Alam et al, 2020). Sirtuins (SIRTs) are a family of class III NAD-dependent deacetylases that have been extensively linked to the regulation of lifespan and the protection of cells against proteotoxicity.…”

Section: Testicular Germ Cellsmentioning

confidence: 99%

Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health

Cafe

Nixon

Ecroyd

et al. 2021

Front. Cell Dev. Biol.

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For fully differentiated, long lived cells the maintenance of protein homeostasis (proteostasis) becomes a crucial determinant of cellular function and viability. Neurons are the most well-known example of this phenomenon where the majority of these cells must survive the entire course of life. However, male and female germ cells are also uniquely dependent on the maintenance of proteostasis to achieve successful fertilization. Oocytes, also long-lived cells, are subjected to prolonged periods of arrest and are largely reliant on the translation of stored mRNAs, accumulated during the growth period, to support meiotic maturation and subsequent embryogenesis. Conversely, sperm cells, while relatively ephemeral, are completely reliant on proteostasis due to the absence of both transcription and translation. Despite these remarkable, cell-specific features there has been little focus on understanding protein homeostasis in reproductive cells and how/whether proteostasis is “reset” during embryogenesis. Here, we seek to capture the momentum of this growing field by highlighting novel findings regarding germline proteostasis and how this knowledge can be used to promote reproductive health. In this review we capture proteostasis in the context of both somatic cell and germline aging and discuss the influence of oxidative stress on protein function. In particular, we highlight the contributions of proteostasis changes to oocyte aging and encourage a focus in this area that may complement the extensive analyses of DNA damage and aneuploidy that have long occupied the oocyte aging field. Moreover, we discuss the influence of common non-enzymatic protein modifications on the stability of proteins in the male germline, how these changes affect sperm function, and how they may be prevented to preserve fertility. Through this review we aim to bring to light a new trajectory for our field and highlight the potential to harness the germ cell’s natural proteostasis mechanisms to improve reproductive health. This manuscript will be of interest to those in the fields of proteostasis, aging, male and female gamete reproductive biology, embryogenesis, and life course health.

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SIRTI and cortisol in unexplained infertile females; a cross sectional study, in Karachi Pakistan

Cited by 10 publications

References 40 publications

Suggested role of silent information regulator 1 (SIRT1) gene in female infertility: A cross‐sectional study in Pakistan

Suggested role of silent information regulator 1 (SIRT1) gene in female infertility: A cross‐sectional study in Pakistan

Oxidative Stress as a Potential Underlying Cause of Minimal and Mild Endometriosis-Related Infertility

Proteostasis in the Male and Female Germline: A New Outlook on the Maintenance of Reproductive Health

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