Sirtuin 1: A Dilemma in Transplantation

Assadiasl, Sara; Mooney, Nuala; Mohebbi, Bahareh; Fatahi, Yousef; Soleimanifar, Narjes

doi:10.1155/2020/9012980

Cited by 8 publications

(6 citation statements)

References 64 publications

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“…SIRT1 is a NAD(+)-dependent deacetylase and thus ethanol mediated decreased NAD + /NADH levels could inhibit SIRT1 activity in liver [18,19]. SIRT1 is highly sensitive to intracellular oxidation state.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

Emerging Roles of SIRT1 in Alcoholic Liver Disease

Ren¹,

Wang²,

Wu³

et al. 2020

Int. J. Biol. Sci.

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Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide with a wide spectrum of liver pathologies ranging from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. It has been demonstrated that ALD is mediated in whole or in part by a central signaling molecule sirtuin 1 (SIRT1), a conserved class III histone deacetylase.SIRT1 plays beneficial roles in regulating hepatic lipid metabolism, inhibiting hepatic inflammation, controlling hepatic fibrosis and mediating hepatocellular carcinoma in ALD. However, underlying molecular mechanisms are complex and remain incompletely understood. The aim of this review was to highlight the latest advances in understanding of SIRT1 regulatory mechanisms in ALD and discuss their unique potential role as novel therapeutic target for ALD treatment.

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Section: Ivyspring International Publishermentioning

confidence: 99%

Emerging Roles of SIRT1 in Alcoholic Liver Disease

Ren¹,

Wang²,

Wu³

et al. 2020

Int. J. Biol. Sci.

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show abstract

“…SIRT 1 can catalyze the deacetylation of PGC-1α, thereby affecting cell metabolism and mitochondrial biogenesis ( Nemoto et al, 2005 ). The expression of SIRT 1 was decreased during I/R injury, and the injury caused by I/R could be alleviated by up-regulating SIRT1 ( Assadiasl et al, 2020 ). SIRT1 has become a potential target to prevent I/R injury.…”

Section: Discussionmentioning

confidence: 99%

Kaempferol Alleviates Oxidative Stress and Apoptosis Through Mitochondria-dependent Pathway During Lung Ischemia-Reperfusion Injury

Chen

Yang

et al. 2021

Front. Pharmacol.

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In previous study, we reported that kaempferol ameliorates significantly lung ischemia-reperfusion injury (LIRI), and may be achieved by targeting the SIRT 1 pathway. This study further explored the anti-LIRI mechanism of kaempferol. In vitro, the rat alveolar epithelial cells L2 was cultured and subjected to anoxia/reoxygenation (A/R) insult. In vivo, SD rats were operated to establish LIRI model. The related indicators of oxidative stress and apoptosis in L2 cells and rats lung tissues were detected. Results showed that kaempferol pre-treatment significantly increased the cell viability, improved mitochondrial membrane potential, inhibited the opening of mitochondrial permeability transition pores, reduced the levels of oxidative stress and apoptosis, increased the expressions of Bcl-2 and mitochondrial cytochrome c, and decreased the expressions of Bax and cytoplasmic cytochrome c in L2 cells after A/R insult. In vivo, kaempferol improved the pathological injury, inhibited the levels of oxidative stress and apoptosis, increased the expressions of Bcl-2 and mitochondrial cytochrome c, and decreased the expressions of Bax and cytoplasmic cytochrome c in rats lung tissues after I/R. However, the aforementioned effects of kaempferol were significantly attenuated by the SIRT 1 inhibitor EX527 or the PGC-1α inhibitor SR-18292. What’s more, SR-18292 has not reversed the effect of kaempferol on increasing the protein activity of SIRT 1. Above results suggest that kaempferol ameliorates LIRI by improving mitochondrial function, reducing oxidative stress and inhibiting cell apoptosis. Its molecular mechanism of action includes the SIRT 1/PGC-1α/mitochondria signaling pathway.

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“…The role of the anti-aging gene Sirtuin 1 for example is critical to heart function and Sirtuin downregulation is associated with endothelial dysfunction and cardiovascular disease. Sirtuin 1 activators versus inhibitors may determine the success of heart transplantation [33][34][35][36][37][38].…”

Section: Figure 4b : Roc Curve Based On the Predicted Values Of Ecmo ...mentioning

confidence: 99%

How Donor Profile Affects the Outcome of Heart Transplant: A New Score to Predict Primary Graft Failure

Hoti

2023

JTCS

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Aim: This study aimed to identify demographic and clinical parameters in donors that could predict the ischaemic time tolerated by the heart transplant in order to increase the number of heart transplantation performed in our centre by expanding the area of graft recruitment. Methods: A single site retrospective study was conducted on 116 heart transplantations performed in our centre between 2013 and 2021. Multivariate logistic regression analyses were used to identify interactions between the different donor parameters. Results: Sex, weight, height, total graft ischemic time were the donor parameters independently correlated with primary graft failure (p < 0.1). The logistic regression model included 11 variables, with an AUC of 0.81, this model appears to perform well in the prediction of primary graft failure in the recipient. Conclusions: A predictive score of primary graft failure was created based on identified donors parameters that may help identify grafts with a higher tolerance to ischemia.

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Sirtuin 1: A Dilemma in Transplantation

Cited by 8 publications

References 64 publications

Emerging Roles of SIRT1 in Alcoholic Liver Disease

Emerging Roles of SIRT1 in Alcoholic Liver Disease

Kaempferol Alleviates Oxidative Stress and Apoptosis Through Mitochondria-dependent Pathway During Lung Ischemia-Reperfusion Injury

How Donor Profile Affects the Outcome of Heart Transplant: A New Score to Predict Primary Graft Failure

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