2023
DOI: 10.1007/s44200-023-00035-3
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Sirtuin 1 and Sirtuin 2 Plasma Concentrations in Patients with Ascending Aortic Dissection and Ascending Aortic Aneurysm

Abstract: Background Previous studies explored multifactorial interactions and sirtuin expression in the aortic cells of laboratory rodents and humans. Human studies were limited due to the availability of biological material exclusively in the advanced stage of the disease. The role of sirtuins in aortic pathology has not been explained extensively therefore the aim of the study was to assess the plasma concentrations of human sirtuin 1 (SIRT1) and human sirtuin 2 (SIRT2) in patients with ascending aortic… Show more

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“…There is an array of data demonstrating chemerin may be intertwined with CKM driving pathways. In humans, SIRT1 concentrations in serum/plasma are lower in patients with aortic aneurysm [34], stroke [35] and prior history of myocardial infarction [36], but also type 2 diabetic nephropathy [37]. Circulating chemerin is associated with dysfunctional adiposity measures (obesity, lipid alterations) and blood pressure [38], as well as being an independent marker of arterial stiffness, even after adjustment for confounders [39].…”
Section: Discussionmentioning
confidence: 99%
“…There is an array of data demonstrating chemerin may be intertwined with CKM driving pathways. In humans, SIRT1 concentrations in serum/plasma are lower in patients with aortic aneurysm [34], stroke [35] and prior history of myocardial infarction [36], but also type 2 diabetic nephropathy [37]. Circulating chemerin is associated with dysfunctional adiposity measures (obesity, lipid alterations) and blood pressure [38], as well as being an independent marker of arterial stiffness, even after adjustment for confounders [39].…”
Section: Discussionmentioning
confidence: 99%