Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism

Liao, Zhihao; Cai, Xuepei; Zheng, Yifan; Lin, Jiayu; Yang, Xia; Lin, Weiyin; Zhang, Ying; He, Xin; Liu, Chufeng

doi:10.1016/j.phrs.2024.107141

Pharmacological Research

2024

DOI: 10.1016/j.phrs.2024.107141

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Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism

Zhihao Liao,

Xuepei Cai,

Yifan Zheng

et al.

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2024

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Cited by 3 publications

References 146 publications

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The role of sirtuins in intervertebral disc degeneration: Mechanisms and therapeutic potential

Tu,

Gao,

Zhou

et al. 2024

Journal Cellular Physiology

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Intervertebral disc degeneration (IDD) is one of the main causes of low back pain, which affects the patients' quality of life and health and imposes a significant socioeconomic burden. Despite great efforts made by researchers to understand the pathogenesis of IDD, effective strategies for preventing and treating this disease remain very limited. Sirtuins are a highly conserved family of (NAD+)‐dependent deacetylases in mammals that are involved in a variety of metabolic processes in vivo. In recent years, sirtuins have attracted much attention owing to their regulatory roles in IDD on physiological activities such as inflammation, apoptosis, autophagy, aging, oxidative stress, and mitochondrial function. At the same time, many studies have explored the therapeutic effects of sirtuins‐targeting activators or micro‐RNA in IDD. This review summarizes the molecular pathways of sirtuins involved in IDD, and summarizes the therapeutic role of activators or micro‐RNA targeting Sirtuins in IDD, as well as the current limitations and challenges, with a view to provide possible solutions for the treatment of IDD.

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The role of sirtuins in intervertebral disc degeneration: Mechanisms and therapeutic potential

Tu,

Gao,

Zhou

et al. 2024

Journal Cellular Physiology

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An “All‐in‐One” Strategy to Reconstruct Temporomandibular Joint Osteoarthritic Microenvironment Using γ‐Fe₂O₃@TA@ALN Nanoparticles

Cen,

Deng,

Pan

et al. 2024

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Current clinical strategies for the treatment of temporomandibular joint osteoarthritis (TMJOA) primarily target cartilage biology, overlooking the synergetic effect of various cells and inorganic components in shaping the arthritic microenvironment, thereby impeding the effectiveness of existing therapeutic options for TMJOA. Here, γ‐Fe2O3@TA@ALN magnetic nanoparticles (γ‐Fe2O3@TA@ALN MNPs) composed of γ‐Fe2O3, tannic acid (TA), and alendronate sodium (ALN) are engineered to reconstruct the osteoarthritic microenvironment and mitigate TMJOA progression. γ‐Fe2O3@TA@ALN MNPs can promote chondrocytes’ proliferation, facilitate chondrogenesis and anisotropic organization, enhance lubrication and reduce cartilage wear, and encourage cell movement. Magnetic‐responsive γ‐Fe2O3@TA@ALN MNPs also exhibit pH sensitivity, which undergoes decomposition within acidic environment to release ALN on demand. Under a 0.2 T static magnetic field, γ‐Fe2O3@TA@ALN MNPs accelerate the synthesis of cartilage‐specific proteins, and suppress catabolic‐related genes expression and reactive oxygen species generation, affording additional protection to TMJ cartilage. In TMJOA mouse models, articular injection of γ‐Fe2O3@TA@ALN MNPs effectively alleviates cartilage degeneration and subchondral bone loss in short and long terms, offering promising avenues for the development of therapeutic interventions for TMJOA.

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SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets

Yang,

Liu,

Jiang

et al. 2024

Biomedicine & Pharmacotherapy

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Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism

Cited by 3 publications

References 146 publications

The role of sirtuins in intervertebral disc degeneration: Mechanisms and therapeutic potential

The role of sirtuins in intervertebral disc degeneration: Mechanisms and therapeutic potential

An “All‐in‐One” Strategy to Reconstruct Temporomandibular Joint Osteoarthritic Microenvironment Using γ‐Fe₂O₃@TA@ALN Nanoparticles

SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets

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Sirtuin 1 in osteoarthritis: Perspectives on regulating glucose metabolism

Cited by 3 publications

References 146 publications

The role of sirtuins in intervertebral disc degeneration: Mechanisms and therapeutic potential

The role of sirtuins in intervertebral disc degeneration: Mechanisms and therapeutic potential

An “All‐in‐One” Strategy to Reconstruct Temporomandibular Joint Osteoarthritic Microenvironment Using γ‐Fe2O3@TA@ALN Nanoparticles

SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets

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An “All‐in‐One” Strategy to Reconstruct Temporomandibular Joint Osteoarthritic Microenvironment Using γ‐Fe₂O₃@TA@ALN Nanoparticles