Sirtuin 7: a new marker of aggressiveness in prostate cancer

Haider, Romain; Massa, Fabienne; Kaminski, Lisa; Clavel, Stéphan; Djabari, Zied; Robert, Guillaume; Laurent, Kathiane; Michiels, Jean‐François; Durand, Matthieu; Ricci, Jean-Ehrland; Tanti, Jean‐François; Bost, Fréd́eric

doi:10.18632/oncotarget.20468

Cited by 28 publications

(36 citation statements)

References 28 publications

(31 reference statements)

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“…Whether SIRT7 mRNA expression significantly differs between cancerous and normal prostate tissues is controversial [15,16]. Thus, we evaluated the SIRT7 expression levels reported in published profiles of patients with PCa [23][24][25].…”

Section: Sirt7 Is Upregulated In Pca and Correlates With Poor Patientmentioning

confidence: 99%

“…Previous studies mainly focused on the influence of SIRT7 on PCa metastasis [15,16]. However, the effects of SIRT7 on PCa cell proliferation are unclear.…”

Section: Sirt7 Promotes Pca Cell Proliferation In Vitromentioning

confidence: 99%

“…5c, d). We applied the Allred score [15,22] to quantify the expression of SIRT7 and identify the correlation between SIRT7 and serum PSA. The SIRT7 expression showed higher mean Allred scores in tumors with PSA ≥ 10 ng mL − 1 (P = 0.0018) and PSA = 4-10 ng mL − 1 (P = 0.0288) than in those with PSA < 4 ng mL − 1 (Fig.…”

Section: Sirt7 Upregulation In Prostate Cancer Tissues Correlates Witmentioning

confidence: 99%

“…The roles of SIRT7 in various tumors have been proposed but remain controversial [11][12][13][14]. Recently, two studies reported the effects of SIRT7 in PCa [15,16]. They found that elevated SIRT7 levels enhance tumor aggressiveness by promoting epithelial-tomesenchymal transition (EMT).…”

Section: Introductionmentioning

confidence: 99%

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SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer

Ding

Jiang

Zhao

et al. 2020

J Exp Clin Cancer Res

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Background: Sirtuin-7 (SIRT7) is associated with the maintenance of tumorigenesis. However, its functional roles and oncogenic mechanisms in prostate cancer (PCa) are poorly understood. Here, we investigated the roles and underlying molecular mechanisms of SIRT7 in PCa cell growth and androgen-induced autophagy. Methods: The LNCap and 22Rv1 PCa cell lines were subjected to quantitative reverse transcription (RT)-PCR to characterize their genes encoding SIRT7, AR, and SMAD4. The proteins produced from these genes were quantified by western blotting and immunoprecipitation analysis. SIRT7-depleted cells were produced by transfection with plasmid vectors bearing short hairpin RNAs against SIRT7. The proliferation of each cell line was assessed by CCK8 and EdU assays. Autophagic flux was tracked by mRFP-GFP-LC3 adenovirus under an immunofluorescence microscope. Apoptosis was evaluated by flow cytometry. Tumors were induced in mouse axillae by injection of the cell lines into mice. Tumor morphology was examined by immunohistochemistry and relative tumor growth and metastases were compared by a bioluminescence-based in vivo imaging system. Results: SIRT7 depletion significantly inhibited cell proliferation, androgen-induced autophagy, and invasion in LNCap and 22Rv1 cells (in vitro) and mouse xenograft tumors induced by injection of these cells (in vivo). SIRT7 knockdown also increased the sensitivity of PCa cells to radiation. Immunohistochemical analysis of 93 specimens and bioinformatic analysis revealed that SIRT7 expression was positively associated with androgen receptor (AR). Moreover, the AR signal pathway participated in SIRT7-mediated regulation of PCa cell proliferation, autophagy, and invasion. SIRT7 depletion downregulated the AR signal pathway by upregulating the level of SMAD4 protein in PCa cells. Conclusion: SIRT7 plays an important role in the development and progression of human PCa and may be a promising prognostic marker for prostate cancer.

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Section: Sirt7 Is Upregulated In Pca and Correlates With Poor Patientmentioning

confidence: 99%

“…Previous studies mainly focused on the influence of SIRT7 on PCa metastasis [15,16]. However, the effects of SIRT7 on PCa cell proliferation are unclear.…”

Section: Sirt7 Promotes Pca Cell Proliferation In Vitromentioning

confidence: 99%

Section: Sirt7 Upregulation In Prostate Cancer Tissues Correlates Witmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer

Ding

Jiang

Zhao

et al. 2020

J Exp Clin Cancer Res

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“…或预后的预测因子 [67,86,92,98] , 如结直肠癌和胰腺癌的预后生物标志物 [ 9 2 ] 、头颈部鳞状细胞癌的循环标志物 [67] 以及膀胱癌侵袭性的预测生物标志物 [105] . 目前,…”

Section: Sirt7通过与sirt1相互作用抑制e-cadherin的表达促unclassified

The current progress of histone deacetylase SIRT7

Zhan¹,

Xiong²,

Huang³

et al. 2020

Sci. Sin.-Vitae

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Epigenetics as a Key Factor in Prostate Cancer

Enikeeva,

Rafikova,

Sharifyanova

et al. 2024

Advanced Biology

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Nowadays, prostate cancer is one of the most common forms of malignant neoplasms in men all over the world. Against the background of increasing incidence, there is a high mortality rate from prostate cancer, which is associated with an inadequate treatment strategy. Such a high prevalence of prostate cancer requires the development of methods that can ensure early detection of the disease, improve the effectiveness of treatment, and predict the therapeutic effect. Under these circumstances, it becomes crucial to focus on the development of effective diagnostic and therapeutic approaches. Due to the development of molecular genetic methods, a large number of studies have been accumulated on the role of epigenetic regulation of gene activity in cancer development, since it is epigenetic changes that can be detected at the earliest stages of cancer development. The presence of epigenetic aberrations in tumor tissue and correlations with drug resistance suggest new therapeutic approaches. Detection of epigenetic alterations such as CpG island methylation, histone modification, and microRNAs as biomarkers will improve the diagnosis of the disease, and the use of these strategies as targets for therapy will allow for greater personalization of prostate cancer treatment.

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Sirtuin 7: a new marker of aggressiveness in prostate cancer

Cited by 28 publications

References 28 publications

SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer

SIRT7 depletion inhibits cell proliferation and androgen-induced autophagy by suppressing the AR signaling in prostate cancer

The current progress of histone deacetylase SIRT7

Epigenetics as a Key Factor in Prostate Cancer

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