Sirtuin1 expression and survival in endometrial and clear-cell uterine cancer

Abstract

Several risk factors like obesity and hyperlipidemia were described for endometrial cancer. Here, the nuclear NAD-dependent histone-deacetylase Sirtuin1 (SIRT1) seems to be important. SIRT1 is also involved in cell regulatory mechanisms and can serve as tumor promotor or suppressor. Its role in tumor biology is not clear yet. In this study, we evaluated and correlated the SIRT1 expression with patients' tumor characteristics in endometrioid and clear-cell cancer of the uterus. 65 paraffinembedded samples of patients with endometrial and clear-cell cancer of the uterus were immunohistochemically stained and SIRT1 expression was evaluated by immunoreactive score. The results were correlated to clinical and pathological tumor characteristics as well as to the expression of ARID1A and β-Catenin. The staining was significantly more intensive in uterine endometrioid carcinoma compared to uterine clear-cell carcinoma (p = 0.007). The expression of SIRT1 correlated significantly with the membranous expression of β-Catenin (p = 0.028) and ARID1A (p = 0.021). Patients with positive Sir-tuin1 expression had a significantly better progression-free survival (p = 0.042), the overall survival showed a trend towards a better prognosis (p = 0.070). SIRT1 expression seems to be associated with improved progression-free survival in uterine cancer (endometrioid and clear-cell) and is correlated to the tumor suppressors β-Catenin and ARID1A. Further studies are necessary to elucidate the role of SIRT1 in uterine and ovarian cancer and its potential as a therapeutic target.

Effect Of Puerarin on The Growth of Nasopharyngeal Carcinoma Cells and Its Impact on Angiogenesis

“…Current cancer research efforts focus on epigenetic alterations that may be related to Sirtuin (SIRT) 1-7 [39]. In recent years, SIRT1 is considered to be the most characteristic sirtuin in seven members.…”

Targeting Epigenetic Regulators for Endometrial Cancer Therapy: Its Molecular Biology and Potential Clinical Applications

“…High SIRT1 expression in patients with EC is associated with better overall survival and progression-free survival than patients with low SIRT1 expression. This indicates that SIRT1 may be a tumor suppressor [ 77 ] ( Table 2 ).…”

In focus in HCB

“…For instance, in endometrial and ovarian epithelial cancers, an increase in its expression has been described (Asaka et al 2015;Bartosch et al 2016;Jang et al 2009), correlated with improved overall survival in ovarian cancer, but lower survival rates in endometrial cancer. Beyer et al (2020) have now investigated the immunohistochemical staining of SIRT1 in endometrial type-I carcinomas and clear cell carcinomas of the uterus in an attempt to correlate its expression with clinical parameters including patient survival. Their study cohort included 59 cases of endometroid carcinoma and 6 cases of clear cell uterine carcinoma.…”