Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis

Cekici, Ali; Sahinkaya, Selin; Donmez, M. Fatih; Turkmen, Emrah; Balci, Nur; Toygar, Hilal

doi:10.1007/s00784-023-05330-6

Clin Oral Invest

2023

DOI: 10.1007/s00784-023-05330-6

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Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis

Ali Cekici,

Selin Sahinkaya,

M. Fatih Donmez

et al.

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2024

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Cited by 1 publication

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A potent proresolving mediator 17R-resolvin D2 from human macrophages, monocytes, and saliva

Simard,

Nshimiyimana,

Chiang

et al. 2024

Sci. Adv.

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Production of specialized proresolving mediators (SPMs) during the resolution phase in the acute inflammatory response is key to orchestrating complete resolution. Here, we uncovered a trihydroxy resolvin in fresh human saliva. We identified and determined its complete stereochemistry as 7S,16R,17R-trihydroxy-4Z,8E,10Z,12E,14E,19Z-docosahexaenoic acid (17R-RvD2) using total organic synthesis and matching of physical properties. The 17R-RvD2 was produced by activated human M2-like macrophages, M1-like macrophages, and human peripheral blood monocytes. 17R-RvD2 displayed potent proresolving functions (picomolar to nanomolar). Topical application of 17R-RvD2 on mouse ear skin reduced neutrophilic infiltration (~50%). 17R-RvD2 increased M2 markers CD206 and CD163 on human monocyte–derived macrophages and enhanced efferocytosis of senescent red blood cells by M2-like macrophages (EC 50 ~ 2.6 × 10 −14 M). In addition, 17R-RvD2 activated the RvD2 receptor and was equipotent to its epimer RvD2. 17R-RvD2 also significantly increased phagocytosis of Escherichia coli by human neutrophils. Together, these results establish the complete stereochemistry and potent proresolving functions of the previously unknown 17R-RvD2.

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A potent proresolving mediator 17R-resolvin D2 from human macrophages, monocytes, and saliva

Simard,

Nshimiyimana,

Chiang

et al. 2024

Sci. Adv.

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show abstract

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Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis

Cited by 1 publication

References 45 publications

A potent proresolving mediator 17R-resolvin D2 from human macrophages, monocytes, and saliva

A potent proresolving mediator 17R-resolvin D2 from human macrophages, monocytes, and saliva

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