Sirtuins and aging

Morris, Brian J.

doi:10.1016/b978-0-12-814118-2.00017-3

Sirtuin Biology in Medicine 2021

DOI: 10.1016/b978-0-12-814118-2.00017-3

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Sirtuins and aging

Brian J. Morris

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2024

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Cited by 2 publications

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Histone acylation at a glance

Bhattacharya,

2024

Journal of Cell Science

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An important mechanism of gene expression regulation is the epigenetic modification of histones. The cofactors and substrates for these modifications are often intermediary metabolites, and it is becoming increasingly clear that the metabolic and nutritional state of cells can influence these marks. These connections between the balance of metabolites, histone modifications and downstream transcriptional changes comprise a metabolic signaling program that can enable cells to adapt to changes in nutrient availability. Beyond acetylation, there is evidence now that histones can be modified by other acyl groups. In this Cell Science at a Glance article and the accompanying poster, we focus on these histone acylation modifications and provide an overview of the players that govern these acylations and their connections with metabolism.

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Histone acylation at a glance

Bhattacharya,

2024

Journal of Cell Science

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Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

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Augustyniak

2022

IJMS

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The sirtuin system consists of seven highly conserved regulatory enzymes responsible for metabolism, antioxidant protection, and cell cycle regulation. The great interest in sirtuins is associated with the potential impact on life extension. This article summarizes the latest research on the activity of sirtuins and their role in the aging process. The effects of compounds that modulate the activity of sirtuins were discussed, and in numerous studies, their effectiveness was demonstrated. Attention was paid to the role of a caloric restriction and the risks associated with the influence of careless sirtuin modulation on the organism. It has been shown that low modulators’ bioavailability/retention time is a crucial problem for optimal regulation of the studied pathways. Therefore, a detailed understanding of the modulator structure and potential reactivity with sirtuins in silico studies should precede in vitro and in vivo experiments. The latest achievements in nanobiotechnology make it possible to create promising molecules, but many of them remain in the sphere of plans and concepts. It seems that solving the mystery of longevity will have to wait for new scientific discoveries.

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Sirtuins and aging

Cited by 2 publications

References 297 publications

Histone acylation at a glance

Histone acylation at a glance

Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future

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