Sirtuins as Potential Therapeutic Targets for Hepatitis B Virus Infection

Kong, Fanyun; Li, Qi; Zhang, Fulong; Li, Xiaocui; You, Hua; Pan, Xiucheng; Zheng, Kuiyang; Tang, Renxian

doi:10.3389/fmed.2021.751516

Cited by 13 publications

(9 citation statements)

References 46 publications

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“…In addition, the role of SIRT2 in infections has recently begun to be explored ( 27 ). Specifically, SIRT2 accelerates viral replication of hepatitis B virus (HBV), and the use of sirtuin inhibitors has been proposed as potential new therapeutic interventions ( 35 , 36 ). In Listeria monocytogenes infection, SIRT2 translocates to the nucleus and deacetylates H3K18, which associates with a subset of host genes that are crucial during the bacterial life cycle ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction

Duran-Castells

Llano

Kawana-Tachikawa

et al. 2023

J Virol

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Neurocognitive disorders are frequently reported in people living with HIV (PLWH) even with the introduction of combined antiretroviral treatment (cART). To identify biomarkers and potential therapeutic tools to target HIV infection in peripheral blood and in the central nervous system (CNS), plasma proteomics were applied in untreated chronic HIV-infected individuals with different levels of virus control.

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Section: Discussionmentioning

confidence: 99%

Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction

Duran-Castells

Llano

Kawana-Tachikawa

et al. 2023

J Virol

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“…During HBV infection, viral proteins including HBX and HBp have evolved multiple strategies to regulate the expression of different DEAD/H-box helicases to facilitate infection. Especially, HBX is a multifunctional viral molecule that is essential for HBV replication and associated diseases (Kong et al, 2019;Kong et al, 2021a;Kong et al, 2021c;You et al, 2022). This review examines various evidence that indicates HBX regulates different DEAD/H-box helicases, including DHX9, RIG-I, and MDA5.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The emerging role of DEAD/H-box helicases in hepatitis B virus infection

You

Ma²,

Wang³

et al. 2022

Front. Cell. Infect. Microbiol.

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DEAD/H-box helicases are an essential protein family with a conserved motif containing unique amino acid sequences (Asp-Glu-Ala-Asp/His). Current evidence indicates that DEAD/H-box helicases regulate RNA metabolism and innate immune responses. In recent years, DEAD/H-box helicases have been reported to participate in the development of a variety of diseases, including hepatitis B virus (HBV) infection, which is a significant risk factor for hepatic fibrosis, cirrhosis, and liver cancer. Furthermore, emerging evidence suggests that different DEAD/H-box helicases play vital roles in the regulation of viral replication, based on the interaction of DEAD/H-box helicases with HBV and the modulation of innate signaling pathways mediated by DEAD/H-box helicases. Besides these, HBV can alter the expression and activity of DEAD/H-box helicases to facilitate its biosynthesis. More importantly, current investigation suggests that targeting DEAD/H-box helicases with appropriate compounds is an attractive treatment strategy for the virus infection. In this review, we delineate recent advances in molecular mechanisms relevant to the interplay of DEAD/H-box helicase and HBV and the potential of targeting DEAD/H-box helicase to eliminate HBV infection.

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“…Epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNAs, interfere with the target genes’ transcription and post-transcriptional expression, including clock genes[ 69 ]. Different patterns of histone modifications, such as histone deacetylase sirtuin 1 (SIRT1), or microRNA, can be direct and indirect modulators in maintaining different aspects of circadian rhythm function[ 53 , 70 ].…”

Section: Circadian Rhythmmentioning

confidence: 99%

“…Disorders of the CLOCK and BMAL1 genes lead to impaired glucose homeostasis[ 6 ]. Histone deacetylase SIRT1 prevents hepatic steatosis by controlling lipid homeostasis by positive binding of PPARα and PGC1α coactivators, or by direct action on BMAL1[ 70 ].…”

Section: Circadian Rhythmmentioning

confidence: 99%

Hepatitis B and circadian rhythm of the liver

Škrlec¹,

Talapko²

2022

WJG

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The circadian rhythm in humans is determined by the central clock located in the hypothalamus’s suprachiasmatic nucleus, and it synchronizes the peripheral clocks in other tissues. Circadian clock genes and clock-controlled genes exist in almost all cell types. They have an essential role in many physiological processes, including lipid metabolism in the liver, regulation of the immune system, and the severity of infections. In addition, circadian rhythm genes can stimulate the immune response of host cells to virus infection. Hepatitis B virus (HBV) infection is the leading cause of liver disease and liver cancer globally. HBV infection depends on the host cell, and hepatocyte circadian rhythm genes are associated with HBV replication, survival, and spread. The core circadian rhythm proteins, REV-ERB and brain and muscle ARNTL-like protein 1, have a crucial role in HBV replication in hepatocytes. In addition to influencing the virus’s life cycle, the circadian rhythm also affects the pharmacokinetics and efficacy of antiviral vaccines. Therefore, it is vital to apply antiviral therapy at the appropriate time of day to reduce toxicity and improve the effectiveness of antiviral treatment. For these reasons, understanding the role of the circadian rhythm in the regulation of HBV infection and host responses to the virus provides us with a new perspective of the interplay of the circadian rhythm and anti-HBV therapy. Therefore, this review emphasizes the importance of the circadian rhythm in HBV infection and the optimization of antiviral treatment based on the circadian rhythm-dependent immune response.

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Sirtuins as Potential Therapeutic Targets for Hepatitis B Virus Infection

Cited by 13 publications

References 46 publications

Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction

Sirtuin-2, NAD-Dependent Deacetylase, Is a New Potential Therapeutic Target for HIV-1 Infection and HIV-Related Neurological Dysfunction

The emerging role of DEAD/H-box helicases in hepatitis B virus infection

Hepatitis B and circadian rhythm of the liver

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