2012
DOI: 10.1038/nrm3293
|View full text |Cite
|
Sign up to set email alerts
|

Sirtuins as regulators of metabolism and healthspan

Abstract: Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological chan… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

25
1,463
0
12

Year Published

2013
2013
2024
2024

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 1,669 publications
(1,500 citation statements)
references
References 159 publications
(270 reference statements)
25
1,463
0
12
Order By: Relevance
“…These findings suggest that SIRT6 extends lifespan only in male mice potentially by reducing IGF1 signalling specifically in white adipose tissue (WAT; Kanfi et al, 2012). In addition, numerous studies report that sirtuins are crucial regulators of metabolic homeostasis and healthspan (reviewed in Houtkooper et al, 2012;Longo and Kennedy, 2006). Taken together, these studies suggest that although the role of sirtuins as sensu stricto longevity genes may be overestimated, sirtuins play important roles in regulating cellular stress responses, genomic stability and metabolism, major contributors to longevity.…”
Section: Sirtuinsmentioning
confidence: 99%
“…These findings suggest that SIRT6 extends lifespan only in male mice potentially by reducing IGF1 signalling specifically in white adipose tissue (WAT; Kanfi et al, 2012). In addition, numerous studies report that sirtuins are crucial regulators of metabolic homeostasis and healthspan (reviewed in Houtkooper et al, 2012;Longo and Kennedy, 2006). Taken together, these studies suggest that although the role of sirtuins as sensu stricto longevity genes may be overestimated, sirtuins play important roles in regulating cellular stress responses, genomic stability and metabolism, major contributors to longevity.…”
Section: Sirtuinsmentioning
confidence: 99%
“…SIRT1 interacts and deacetylates FOXO3a in oxidative stress (Brunet et al 2004); therefore, SIRT1 increased the FOXO3a-induced cell cycle arrest, but inhibited the FOXO3a-induced cell death. SIRT1 is a NAD + -dependent protein deacetylase which is involved in metabolism, aging, and neuron survival (Houtkooper et al 2012). FOXO1, FOXO3a, FOXO4, p53, PGC1α, NF-κB, and others were known to be SIRT1's substrates (Jiang 2008).…”
Section: Discussionmentioning
confidence: 99%
“…Mammalian sirtuins are localized in different subcellular compartments: SIRT1, -6, and -7 are predominately in the nucleus, SIRT2 is cytoplasmically localized, and SIRT3, -4, and -5 are located in the mitochondria (Frye, 2000;North and Verdin, 2004). SIRT1 targets a number of substrates that regulate DNA damage, stress response, mitochondrial biogenesis, and glu- cose and lipid metabolism (Houtkooper et al, 2012). SIRT2 controls cell cycle and glucose and lipid metabolism (Chalkiadaki and Guarente, 2012;Houtkooper et al, 2012).…”
Section: Overview Of Sirtuinsmentioning
confidence: 99%
“…SIRT1 targets a number of substrates that regulate DNA damage, stress response, mitochondrial biogenesis, and glu- cose and lipid metabolism (Houtkooper et al, 2012). SIRT2 controls cell cycle and glucose and lipid metabolism (Chalkiadaki and Guarente, 2012;Houtkooper et al, 2012). SIRT3, 4, and 5 regulate ATP production, metabolism, apoptosis, and cell signaling (Haigis et al, 2006;Michishita et al, 2005;Onyango et al, 2002;Schwer et al, 2002).…”
Section: Overview Of Sirtuinsmentioning
confidence: 99%
See 1 more Smart Citation