Sirtuins at the Service of Healthy Longevity

Wątroba, Mateusz; Szukiewicz, Dariusz

doi:10.3389/fphys.2021.724506

Cited by 39 publications

(35 citation statements)

References 185 publications

(246 reference statements)

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“…Therefore, the autophagy regulator mTOR plays a central role in determining aging-associated processes [ 34 ]. Sirtuins are other regulators slowing cell and organism aging [ 42 , 43 , 44 ], although the precise mechanisms by which this is attained are unclear. Sirtuins can modulate cell metabolic state and proteostasis at different levels [ 42 , 45 , 46 , 47 , 48 ], as well as counteract genome reprogramming [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

SCA® Slows the Decline of Functional Parameters Associated with Senescence in Skin Cells

Castro

Paz

González

et al. 2022

IJMS

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The identification of compounds and natural ingredients that can counteract tissue stress and dysfunction induced by aging in skin cells is warranted. Here, we investigated the activity of the secretion from the snail Cryptomphalus aspersa (SCA®), an active compound with well-established beneficial effects on skin integrity and aging. To determinate its senescence-regulation mechanisms, we used a model where damage was induced by hydrogen peroxide (H2O2). The results showed that SCA® positively modulated factors involved in cell senescence such as β-galactosidase and cell morphology, secretory efficiency markers (SIRT1/6 and carboxymethyl-lysine), and metabolic and redox homeostasis (mTOR and ROS). This study demonstrated a novel compound that is activity-modulating, reduces cell senescence, and increases longevity to maintain skin homeostasis and functionality.

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Section: Discussionmentioning

confidence: 99%

SCA® Slows the Decline of Functional Parameters Associated with Senescence in Skin Cells

Castro

Paz

González

et al. 2022

IJMS

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“…NAD + levels are increased in fasting, intermittent fasting or caloric restriction, leading to the activation of sirtuins. Activated sirtuins deacetylate a number of proteins playing key roles in metabolism, inflammation, autophagy, aging, apoptosis, oxidative stress, neurodegeneration and cancer [ 286 , 292 ]. SIRT1, the most extensively studied sirtuin, interacts with the clock machinery contributing to the circadian rhythms.…”

Section: Mechanisms Of Chrononutrition In Energy Homeostasis and Obesitymentioning

confidence: 99%

Chrononutrition—When We Eat Is of the Essence in Tackling Obesity

Ahluwalia

2022

Nutrients

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Obesity is a chronic and relapsing public health problem with an extensive list of associated comorbidities. The worldwide prevalence of obesity has nearly tripled over the last five decades and continues to pose a serious threat to wider society and the wellbeing of future generations. The pathogenesis of obesity is complex but diet plays a key role in the onset and progression of the disease. The human diet has changed drastically across the globe, with an estimate that approximately 72% of the calories consumed today come from foods that were not part of our ancestral diets and are not compatible with our metabolism. Additionally, multiple nutrient-independent factors, e.g., cost, accessibility, behaviours, culture, education, work commitments, knowledge and societal set-up, influence our food choices and eating patterns. Much research has been focused on ‘what to eat’ or ‘how much to eat’ to reduce the obesity burden, but increasingly evidence indicates that ‘when to eat’ is fundamental to human metabolism. Aligning feeding patterns to the 24-h circadian clock that regulates a wide range of physiological and behavioural processes has multiple health-promoting effects with anti-obesity being a major part. This article explores the current understanding of the interactions between the body clocks, bioactive dietary components and the less appreciated role of meal timings in energy homeostasis and obesity.

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“…In addition, sirtuins are well-described regulators of aging and have been associated with longevity [ 50 , 51 , 52 ]. Indeed, mice deficient for SIRT1 [ 53 , 54 ], SIRT3 [ 55 ] or SIRT6 [ 56 ] display a shorter life span with severe cardiac damage, such as hypertrophy and fibrosis.…”

Section: Cardiac Acetylationmentioning

confidence: 99%

Cardiac Acetylation in Metabolic Diseases

et al. 2022

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Lysine acetylation is a highly conserved mechanism that affects several biological processes such as cell growth, metabolism, enzymatic activity, subcellular localization of proteins, gene transcription or chromatin structure. This post-translational modification, mainly regulated by lysine acetyltransferase (KAT) and lysine deacetylase (KDAC) enzymes, can occur on histone or non-histone proteins. Several studies have demonstrated that dysregulated acetylation is involved in cardiac dysfunction, associated with metabolic disorder or heart failure. Since the prevalence of obesity, type 2 diabetes or heart failure rises and represents a major cause of cardiovascular morbidity and mortality worldwide, cardiac acetylation may constitute a crucial pathway that could contribute to disease development. In this review, we summarize the mechanisms involved in the regulation of cardiac acetylation and its roles in physiological conditions. In addition, we highlight the effects of cardiac acetylation in physiopathology, with a focus on obesity, type 2 diabetes and heart failure. This review sheds light on the major role of acetylation in cardiovascular diseases and emphasizes KATs and KDACs as potential therapeutic targets for heart failure.

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Sirtuins at the Service of Healthy Longevity

Cited by 39 publications

References 185 publications

SCA® Slows the Decline of Functional Parameters Associated with Senescence in Skin Cells

SCA® Slows the Decline of Functional Parameters Associated with Senescence in Skin Cells

Chrononutrition—When We Eat Is of the Essence in Tackling Obesity

Cardiac Acetylation in Metabolic Diseases

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