2019
DOI: 10.2139/ssrn.3385802
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SIS/Aligned Fibre Scaffold Designed to Meet Layered Oesophageal Tissue Complexity and Properties

Abstract: With donor organs not readily available, the need for a tissue engineered oesophagus remains high, particularly for congenital childhood conditions such as atresia. Previous attempts have not been successful and challenges remain. Small intestine submucosa (SIS) is an acellular matrix material with good biological properties though, as is common with these types of materials, demonstrably poor mechanical properties. In this work, electrospinning was used to mechanically reinforce tubular SIS with poly lactic-c… Show more

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Cited by 5 publications
(6 citation statements)
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“…Its special attributes include good biocompatibility, excellent mechanical properties, regulatable biodegradability, and electrospinnability. However, due to the poor hydrophilicity of PLGA, its applications in regenerative medicine have been limited 8,9 …”
Section: Introductionmentioning
confidence: 99%
“…Its special attributes include good biocompatibility, excellent mechanical properties, regulatable biodegradability, and electrospinnability. However, due to the poor hydrophilicity of PLGA, its applications in regenerative medicine have been limited 8,9 …”
Section: Introductionmentioning
confidence: 99%
“…The reduced bladder capacity of SIS grafted animals following bladder augmentation may be attributed to the mechanical features of SIS. Although SIS is a durable, flexible, viscoelastic material and has been utilized successfully for multiple clinical applications 41,[44][45][46][47] , it lacks structural resilience and can undergo significant graft deformation in vivo, especially in situations where graft size is small (0.5 cm × 0.5 cm × 0.01 cm) as in our bladder augmentation model. Other groups have experienced graft contraction utilizing SIS in non-urological settings 40 .…”
Section: Discussionmentioning
confidence: 99%
“…These demonstrated successful replacement by skeletal muscle and epithelium, but SIS and UBS graft tube repair of circumferential defects were plagued by strictures (27). Addition of synthetic polyesters such as PLGA and poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) to SIS have been used in-vitro to improve the mechanical properties with some positive results but have not yet been trialed in animal models (28,29). Cell-seeded SIS will be discussed in the next section.…”
Section: Scaffolds (Table 1)mentioning
confidence: 99%