Sistema factor de necrosis tumoral y leptina en la enfermedad celíaca

Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor which is expressed by many immune cells. However, there are no data about leptin receptor expression in mast cells. Immunohistochemical and immunofluorescent double stainings showed the expression of leptin and leptin receptors in mast cells in human skin and several parts of the respiratory, gastrointestinal and urogenital tract. Leptin was expressed in mast cells expressing the classification marker chymase, whereas a variable expression was observed in tryptase positive mast cells. For leptin receptors, the expression pattern was tissue dependent and not related to tryptase or chymase expression. Our results demonstrate the expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of leptin on mast cells.

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Human mast cells express leptin and leptin receptors

Taildeman

Pérez-Novo

Rottiers

et al. 2009

Histochem Cell Biol

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Advances in the Diagnosis and Treatment of Osteoporosis

Simmons

Zeitler

Steelman

2007

Advances in Pediatrics

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The pathophysiology of bone disease in gastrointestinal disease

Bernstein

Leslie²

2003

European Journal of Gastroenterology & Hepatology

111

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Reduced bone mass and the increased risk of fracture in gastrointestinal diseases have a multifactorial pathogenesis. Undoubtedly, genetics play an important role, but other factors such as systemic inflammation, malnutrition, hypogonadism, glucocorticoid therapy in inflammatory bowel disease (IBD) and other lifestyle factors, such as smoking or being sedentary, may contribute to reduced bone mass. At a molecular level the proinflammatory cytokines that contribute to the intestinal immune response in IBD and probably also in coeliac disease are also known to enhance bone resorption. The discovery of the role of the receptor to activated NFkappaB (RANK) interaction with its ligand RANKL in orchestrating the balance between bone resorption and formation may link mucosal and systemic inflammation with bone remodelling, since RANK-RANKL are also involved in lymphopoiesis and T-cell apoptosis. Low circulating leptin in response to weight loss in any gastrointestinal disease may be an important factor in reducing bone mass. This report will summarize current concepts regarding gastrointestinal diseases (primarily IBD, coeliac disease and postgastrectomy states) and low bone mass and fracture.

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Sistema factor de necrosis tumoral y leptina en la enfermedad celíaca

Cited by 11 publications

References 29 publications

Human mast cells express leptin and leptin receptors

Human mast cells express leptin and leptin receptors

Advances in the Diagnosis and Treatment of Osteoporosis

The pathophysiology of bone disease in gastrointestinal disease

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