Sister chromatid exchange in lymphocytes from renal transplant recipients with and without cancer

Kelly, Graham; Sheil, A. G. R.

doi:10.1038/bjc.1983.269

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…Additionally, in renal transplant recipients, the amount of chromosomal injury in lymphocytes seems to be related to the occurrence of cancer [18]. However, no published data currently relates the occurrence of MN to distinct surgical procedures or the concomitant therapy typically used in solid organ transplantation.…”

Section: Discussionmentioning

confidence: 99%

Mutagenicity of Immunosuppressive Medications among Renal Transplant Recipients

Rath

Oliveira-Frick²

2009

Am J Nephrol

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Background: Immunosuppressive therapy is essential for patients after renal transplantation, but it may have mutagenic side effects. The frequency of micronuclei (MN) assessed by the cytokinesis block assay is well established in the diagnosis of DNA damage. Methods: We examined 79 patients before and after renal transplantation with the cytokinesis block assay. For MN evaluation, the criteria of the Human Micron Nucleus (HUMN) project were used. Results: Age and sex had no influence on the number of MN before transplantation. Patients with a shorter time on dialysis had fewer MN than patients with a longer time on dialysis. After 3 weeks of immunosuppressive therapy, the ability of cells to proliferate was reduced; therefore, only 36 patients could be analyzed. In these patients, MN frequency rose significantly. There was no linear relationship between MN after transplantation and age, sex, time on dialysis or graft function. The majority of patients (79%) were treated with cyclosporine A, mycophenolate mofetil and methylprednisolone when leaving the hospital. There was no difference between the different therapeutic schemes with regard to MN frequency after transplantation, but patients with mycophenolate mofetil showed less cellular proliferation. The function of the transplanted organ or the occurrence of rejection had no effect on MN frequency after transplantation. Conclusion: In patients with renal transplantation, immunosuppressive therapy intensifies the genotoxic damage of the preceding chronic renal failure.

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Section: Discussionmentioning

confidence: 99%

Mutagenicity of Immunosuppressive Medications among Renal Transplant Recipients

Rath

Oliveira-Frick²

2009

Am J Nephrol

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“…In summary, azathioprine is considered safer than other drugs, such as mycophenolate or alkylating agents, and can be used to replace them in pregnant women with autoimmune disease or organ transplantation. Of some concern, however, older studies reported a rise of sister chromatid exchange frequency in patients treated with azathioprine [37,38]. Whether such a mild chromosome damage may have long-term consequences in the mothers and their newborns is unknown at present.…”

Section: Nucleotide Synthesis Inhibitorsmentioning

confidence: 99%

Fetal Toxicity of Immunosuppressive Drugs in Pregnancy

Ponticelli

Moroni

2018

JCM

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Women affected by autoimmune diseases, organ transplantation, or neoplasia need to continue immunosuppressive treatment during pregnancy. In this setting, not only a careful planning of pregnancy, but also the choice of drugs is critical to preventing maternal complications and minimizing the fetal risks. Some immunosuppressive drugs are teratogenic and should be replaced even before the pregnancy, while other drugs need to be managed with caution to prevent fetal risks, including miscarriage, intrauterine growth restriction, prematurity, and low birth weight. In particular, the increasing use of biologic agents raises the question of their compatibility with reproduction. In this review we present data on the indication and safety in pregnancy of the most frequently used immunosuppressive drugs.

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