Sister chromatid exchanges in patients with oral submucous fibrosis

Ghosh, Pradeep; Madhavi, Radha; Guntur, Mohan; Ghosh, Rishila

doi:10.1016/0165-4608(90)90047-e

Cited by 12 publications

(6 citation statements)

References 19 publications

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“…[6] Chromosomal instability is always associated with neoplastic disorders. [7] Because OSF is considered as a precancerous condition, and the rate of malignant transformation is as high as 7.6% in the Indian subcontinent, the present study was designed to utilize a quantitative assay of SCE in OSF patients.…”

Section: Discussionmentioning

confidence: 99%

“…[9] Later studies on SCE frequencies included betel nut and tobacco chewers,[57] oral leukoplakias,[10] oral cancer[11] and OSF. [311] Increase in SCE was reported in the lymphocytes of patients with betel nut and pan chewers (10.61 ± 2.85), oral leukoplakia (7.95 ± 1.63) and oral cancer (9.38 ± 1.28).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Ghosh et al . (1990)[7] showed an increase in the frequency of SCE in OSF patients (8.12 ± 1.69). Again, in 1991, Adhvaryu et al .…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients

Jeyapradha

Saraswathi

Ranganathan

et al. 2011

J Oral Maxillofac Pathol

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Sister chromatid exchange (SCE) test is a sensitive, biomarker of genotoxic substances. The frequency of SCE in lymphocytes of ten pan chewing patients, oral submucous fibrosis (OSF) patients and age matched healthy controls were investigated. The frequency of mean SCE/cell was found to be 10.428 ± 0.755 in OSF patients, 8.752 ± 0.383 in case of pan chewers as compared to 5.912 ± 0.310 in controls. These values show a significant increase in frequency of SCE/cell in OSF patients and pan chewers when compared with that of healthy controls. There is a positive correlation co-efficient of SCE/cell with frequency, quantity, duration, intensity and period of exposure of pan-parag to oral mucosa in pan chewers and OSF patients indicating genotoxic effect of pan. Thus SCE could be used as a biomarker in chewers also to assess the level of genomic damage and to advocate efficient control measures.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients

Jeyapradha

Saraswathi

Ranganathan

et al. 2011

J Oral Maxillofac Pathol

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“…Malignant transformation rate as high as 7.6% has been reported from the Indian subcontinent over a 17 year period. [ 5 6 8 9 12 23 24 25 26 27 28 29 ]…”

Section: Introduction and Review Of Literaturementioning

confidence: 99%

Evaluation of role of trace elements in oral submucous fibrosis patients: A study on Gujarati population

Jani¹,

Chaudhary²,

Dudhia³

et al. 2017

J Oral Maxillofac Pathol

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Introduction:Oral submucous fibrosis (OSMF), a precancerous condition, is highly prevalent in the Indian subcontinent. Among many trace elements, copper and iron are required for the functioning of numerous enzymes. The biochemical alterations of these trace elements in the serum of patients with premalignant conditions can help in determining the staging of the disease, its appropriate treatment and as an indicator for prognosis.Aims and Objectives:The objective of the study was to evaluate the role of iron and copper as well as to identify the better predictor of the two in the diagnosis and progression of OSMF.Materials and Methods:The study sample consisted of 150 patients, out of which the cases group consisting of 100 OSMF patients and control group consisting of 50 individuals. All the cases were confirmed of having OSMF by histopathological examination. The blood sample was obtained from all 150 patients and evaluated by digital autoanalyzer photometer for serum level of copper and iron by the colorimetric method. The results obtained for cases and controls were compared by statistical analysis.Results:The mean serum copper level increases while the mean serum iron level decreases with the advancement in the severity of clinical and histological stages of OSMF.Conclusion:Biopsy is the gold standard to diagnose OSMF, but it is an invasive and time-consuming technique. However, nowadays, many recent advances are used to diagnose OSMF at an early stage and reduce its progression into late and reversible stages. The trace elements serve as potential prognostic and diagnostic markers for OSMF patients.

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“…The measurement of SCE in peripheral blood lymphocytes was for many years one of the most popular cytogenetic methods for evaluating human genotoxicity and hereditary disease (6,7,8). It has been reported that Bloom's Syndrome lymphocytes, oral submucous fibrosis, ovarian cancer, malignant mesothelioma, cervical cancers, malignant melanoma, and breast cancer were analyzed through manipulated SCE incidence (9)(10)(11)(12)(13)(14). The aim of this study is to determine whether SCE frequency, as an index of chromosomal instability, is a heritable factor for GIC or not.…”

Section: Introductionmentioning

confidence: 99%

Increased Sister Chromatid Exchanges in Patients with Gastrointestinal Cancers and in their First-Degree Relatives

Turgut

Yaşar²,

Yaykaşlı

et al. 2014

Electron J Gen Med

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Gastrointestinal Cancers (GICs) European Journal of General MedicineOriginal Article Eur J Gen Med 2014; 11(2): 94-98 DOI : 10.15197/sabad.1.11. 46 Eur J Gen Med 2014;11(2): 94-98 Increased sister chromatid exchange in gastrointestinal cancers 95 MATERIALS AND METHODSThis study was conducted at Düzce University Medical Faculty, Department of Medical Genetics, Düzce, Turkey. The study groups consisted of 15 GIC patients (2 esophagus, 6 stomach, 6 colon and 1 rectum), 13 relatives and 15 healthy subjects. Approved ethical certificate was obtained from local ethics committee, and written informed consents of the studied cases were obtained. Age, gender, smoking and alcohol consumption status and tumor markers (alpha-fetoprotein, AFP, carcinoembryonic antigen-CEA, carcinogenic antigen (CA) 125, CA19-9, CA15-3) were recorded. Two milliliters of venous blood was drawn using Na-heparinized syringes from each case. Replication Index was calculated by following formula.RPI: R1 + (R2x2) + (R3x3) / R1 + R2 + R3Mitotic index (MTI) was calculated by following formula. MTI: metaphase/metaphase+lymphocyte count Statistical analysisThe frequency of SCE per metaphase in groups was compared by Kruskal Wallis. Mann-Whitney U test was also used. Relationships between parameters were evaluated with the Spearman's correlation analysis. Qualitative data were compared using Chi-square test. Results with 95% confidence interval and p<0.05 were considered significant.

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Sister chromatid exchanges in patients with oral submucous fibrosis

Cited by 12 publications

References 19 publications

Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients

Comparison of the frequency of sister chromatid exchange in pan chewers and oral submucous fibrosis patients

Evaluation of role of trace elements in oral submucous fibrosis patients: A study on Gujarati population

Increased Sister Chromatid Exchanges in Patients with Gastrointestinal Cancers and in their First-Degree Relatives

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