Sister chromatid exchanges in peripheral lymphocytes of workers exposed to benzene, trichloroethylene, or tetrachloroethylene, with reference to smoking habits

Seiji, Kazunori; Jin, Cheng‐Yun; Watanabe, Takao; Nakatsuka, Haruo; Ikeda, Masayuki

doi:10.1007/bf00383594

Cited by 46 publications

(17 citation statements)

References 31 publications

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“…Most chronic and complex diseases are likely caused by interactions among environmental exposure, genetic polymorphism, and lifestyles (34) such as smoking and alcohol consumption, which have been identified as risk factors for CBP (54,55). In this study, reduced risk of CBP for alcohol users with APE1 148Asp/Glu+Glu/Glu genotypes was found; however, the matching design may have masked the effect of smoking and alcohol consumption on risk of CBP.…”

Section: Discussionmentioning

confidence: 56%

Genetic Polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and Risk of Chronic Benzene Poisoning in a Chinese Occupational Population

Zhang

Wan

Jin

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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DNA damage induced by benzene is an important mechanism of its genotoxicity that leads to chronic benzene poisoning (CBP). Therefore, genetic variation in DNA repair genes may contribute to susceptibility to CBP in the exposed population. Because benzene-induced DNA damage includes single-and double-strand breaks, we hypothesized that single-nucleotide polymorphisms in X-ray repair crosscomplementing group 1 (XRCC1), apurinic/apyrimidinic endonuclease (APE1), ADP ribosyltransferase (ADPRT), X-ray repair cross-complementing group 2 (XRCC2), and X-ray repair cross-complementing group 3 (XRCC3) are associated with risk of CBP. We genotyped single-nucleotide polymorphisms at codons 194, 280, and 399 of XRCC1, codon 148 of APE1, codon 762 of ADPRT, codon 188 of XRCC2, and codon 241 of XRCC3 in 152 CBP patients and 152 healthy workers frequency matched on age and sex among those who were occupationally exposed to benzene. The genotypes were determined by PCR-RFLP technique with genomic DNA. We found that no individuals had the XRCC2 codon 188 variant alleles or Met/Met genotype of XRCC3 codon 241 in this study population. However, individuals carrying the XRCC1 194Trp allele (i.e., Arg/Trp+Trp/Trp genotypes) had a decreased risk of CBP [adjusted odds ratio (OR adj ), 0.60; 95% confidence interval (95% CI), 0.37-0.98; P = 0.041] compared with subjects with the Arg/Arg genotype whereas individuals carrying the XRCC1 280His allele (i.e., Arg/His+His/His genotypes) had an increased risk of CBP compared with those with the Arg/Arg genotype (OR adj , 1.91; 95% CI, 1.17-3.10; P = 0.009). The analysis of haplotypes of polymorphisms in XRCC1 showed that there was a 2.96-fold (OR, 2.96; 95% CI, 1.60-5.49; C 2 = 12.39, P = 0.001) increased risk of CBP for subjects with alleles of XRCC1 194Arg, XRCC1 280His, and XRCC1 399Arg compared with those carrying alleles of XRCC1 194Arg, XRCC1 280Arg, and XRCC1 399Arg. Therefore, our results suggest that polymorphisms at codons 194 and 280 of XRCC1 may contribute to CBP in a Chinese occupational population. (Cancer Epidemiol Biomarkers Prev 2005;14(11):2614 -9)

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Section: Discussionmentioning

confidence: 56%

Genetic Polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and Risk of Chronic Benzene Poisoning in a Chinese Occupational Population

Zhang

Wan

Jin

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Whether SCEs are increased in benzene-exposed workers is unsettled. Early studies conducted during the 1980s showed mostly negative results (Sarto et al, 1984;Seiji et al, 1990;YardleyJones et al, 1988). In one report, a slight decrease in SCEs was detected (Watanabe et al, 1980).…”

Section: Sister Chromatid Exchanges (Sces)mentioning

confidence: 99%

The Nature of Chromosomal Aberrations Detected in Humans Exposed to Benzene

Zhang¹,

Eastmond

Smith³

2002

Critical Reviews in Toxicology

151

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“…Although genetic polymorphisms play an important role in the expression of diseases, most chronic and complex illnesses are likely caused by interactions among environmental exposure, genetic polymorphisms, and lifestyle behaviors (21), such as tobacco and alcohol consumption, all of which are known risk factors for CBP (49,50). This study found reduced odds of CBP for non-alcohol users with the p21 98A or 70T allele and nonsmokers with the p21 98A allele.…”

Section: Discussionmentioning

confidence: 58%

Association of Genetic Polymorphisms, mRNA Expression ofp53andp21with Chronic Benzene Poisoning in a Chinese Occupational Population

Sun

Qiu

Zhang

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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DNA damage induced by benzene reactive metabolites is thought of as an important mechanism underlying benzene hematotoxicity and genotoxicity, and genetic variation in cell-cycle control genes may contribute to susceptibility to chronic benzene poisoning (CBP). Using a case-control study that included 307 benzene-poisoned patients and 299 workers occupationally exposed to benzene in south China, we aimed to investigate the association between genetic polymorphisms of p53 and p21 and the odds of CBP. To investigate whether benzene exposure may influence mRNA expression of p53 and p21 in benzene-exposed workers, we also chose 39 CBP workers, 38 occupationally benzene-exposure workers, and 37 nonexposure workers in the same region of China. PCR-restriction fragment length polymorphism technique was applied to detect polymorphisms of p53 (rs17878362, rs1042522, and rs1625895) and p21 (rs1801270 and rs1059234), and real-time PCR was applied to detect the quantity of gene mRNA expression. We found that p21 C98A variant genotypes (CA+AA) or C70T variant genotypes (CT+TT) were associated with decreased odds of CBP [odds ratio (OR), 0.51; 95% confidence interval (95% CI), 0.32-0.83, and OR, 0.53; 95% CI, 0.29-0.95, respectively. Further analysis showed the decreased odds of CBP in the subjects with p21 CC/AT diplotype (OR, 0.51; 95% CI, 0.30-0.85). In addition, p53 mRNA expression of CBP workers or benzene-exposure workers was significantly lower than that of nonexposure workers. Although these results require confirmation and extension, our results show that polymorphisms in p21 may be protective against the risk of CBP in the Chinese occupational population. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1821-8)

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Sister chromatid exchanges in peripheral lymphocytes of workers exposed to benzene, trichloroethylene, or tetrachloroethylene, with reference to smoking habits

Cited by 46 publications

References 31 publications

Genetic Polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and Risk of Chronic Benzene Poisoning in a Chinese Occupational Population

Genetic Polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and Risk of Chronic Benzene Poisoning in a Chinese Occupational Population

The Nature of Chromosomal Aberrations Detected in Humans Exposed to Benzene

Association of Genetic Polymorphisms, mRNA Expression ofp53andp21with Chronic Benzene Poisoning in a Chinese Occupational Population

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