Sister Mary Joseph Nodule from Metastatic Renal Cell Carcinoma

Chen, Phebe; Middlebrook, Michael R.; Goldman, Stanford M.; Sandler, Carl M.

doi:10.1097/00004728-199809000-00017

Cited by 24 publications

(11 citation statements)

References 5 publications

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“…Intraperitoneal spread may occur as a result of disruption of the renal capsule [16]. The dissemination of neoplastic cell through the urachus is assumed to be the mechanism for the bladder cancers.…”

Section: Introductionmentioning

confidence: 99%

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Umbilical metastases: current viewpoint

et al. 2005

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BACKGROUND: Umbilical metastases from a malignant neoplasm, also termed Sister Mary Joseph's nodule, are not commonly reported in the English literature, and they have usually been considered as a sign of a poor prognosis for the patient. The present article reports on the current view point on umbilical metastasis besides discussing the epidemiology, clinical presentation, pathophysiology and treatment. METHOD: A search of Pubmed was carried out using the term 'umblic*' and 'metastases' or metastasis' revealed no references. Another search was made using the term "Sister Joseph's nodule" or sister Joseph nodule" that revealed 99 references. Of these there were 14 review articles, however when the search was limited to English language it yielded only 20 articles. Articles selected from these form the basis of this report along with cross references. RESULTS: The primary lesions usually arise from gastrointestinal or genitourinary tract malignancies and may be the presenting symptom or sign of a primary tumour in an unknown site. CONCLUSION: A careful evaluation of all umbilical lesions, including an early biopsy if appropriate, is recommended. Recent studies suggest an aggressive surgical approach combined with chemotherapy for such patients may improve survival.

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Section: Introductionmentioning

confidence: 99%

“…Certain data has shown a better survival (mean 9.7 months) in patients who detect an umbilical metastasis before definitive treatment of the primary tumour. In contrast, when the lesion appears after the primary tumour has been treated then the survival for these patients does not exceed the 7.6 months [16,17]. …”

Section: Introductionmentioning

confidence: 99%

Umbilical metastases: current viewpoint

et al. 2005

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“…Patient prognosis, although dependent on the type and site of the primary tumour, remains rather poor. If the umbilical nodule is detected before treatment, the mean survival is 9.7 months, but when it appears as a sign of recurrence the mean survival falls to 7.6 months [14,15]. Nevertheless, treatment should be individualized and include surgery, chemotherapy and/or radiation therapy aiming to an improved prognosis.…”

Section: Discussionmentioning

confidence: 99%

Umbilical Metastasis as Primary Manifestation of Cancer: A Small Series and Review of the Literature

Psarras

Symeonidis

Baltatzis

et al. 2014

JCDR

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“…Furthermore, spreading may occur through the urachus, remains of the omphalomesenteric duct, and falciform ligament. [9][10][11][12] Usually the finding of an umbilical metastasis bears a poor prognosis consistent with advanced neoplastic disease, usually not amenable to surgery. 13 Survival of patients not treated ranges between 2 and 11 months from the time of diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Sister Mary Joseph's Nodule as a First Sign of Cancer of the Cecum: Report of a Case

Borghese

Conte

et al. 2004

Diseases of the Colon &Amp; Rectum

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Key words: Sister Mary Joseph; Umbilical metastasis; Cecum cancer]C utaneous metastases of malignant neoplasms are not common, occurring between 0.7 and 9 percent of autopsy evaluations. 1 Those to the umbilicus, also known as Sister Mary Joseph's nodule, are even more rare and represent only 10 percent of all secondaries to the skin. 2 These nodules usually arise from the gastrointestinal or genitourinary tract and may represent the first sign of a previously unknown primary tumor. This case demonstrates a Sister Mary Joseph's nodule caused by an unknown primary cancer of the cecum. REPORT OF A CASEA 66-year-old female presented with a six-month history of umbilical lump, initially with a diameter of 0.5 cm, covered by erythematous skin. This was initially treated with conservative measures by a dermatologist, who three months later performed a biopsy. Histology showed cutaneous metastasis caused by a primary occult adenocarcinoma.Five months after the onset of the umbilical lesion, although the diagnostic work-up was still in progress, the patient required an emergency admission for intestinal obstruction. Physical examination of the abdomen showed an erythematous umbilical nodule (diameter of 1.5 cm) with irregular and ill-defined edges, attached to the underlying layers, and of fibrous consistency (Fig. 1). At laparotomy, there was a cecal neoplastic lesion attached to the anterior peritoneum in the umbilical area. A right colectomy with complete excision of the umbilical lesion was performed. Histology of the operative specimen showed a moderately differentiated adenocarcinoma. The skin and subcutaneous tissue specimen presented a central raised lesion consisting of metastases of the primary adenocarcinoma. Pathologic staging was pT3 pN2 pM1. After discharge, the patient received six courses of doxorubicin and died 21 months after surgery. DISCUSSIONUmbilical neoplastic nodules are rare and can be caused by 1) primary tumor (38 percent of cases), 2) endometriosis (32 percent), and 3) metastases (30 percent).

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Sister Mary Joseph Nodule from Metastatic Renal Cell Carcinoma

Cited by 24 publications

References 5 publications

Umbilical metastases: current viewpoint

Umbilical metastases: current viewpoint

Umbilical Metastasis as Primary Manifestation of Cancer: A Small Series and Review of the Literature

Sister Mary Joseph's Nodule as a First Sign of Cancer of the Cecum: Report of a Case

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