Sister Mary Joseph nodule in mantle cell lymphoma

O'Connor-Byrne, Niamh; Glavey, Siobhán; Freitas, Declan de; Quinn, John

doi:10.1016/s1470-2045(20)30203-5

Cited by 2 publications

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“…In women, the most frequent primary locations are ovarian cancer (34%), endometrial cancer (12%), and colorectal cancer (12%) [1]. Other rare causes have also been reported, such as lymphoma [6] and metastatic prostate cancer [7]. Not all umbilical nodules represent malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2023

IJCMCR

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Sister Mary Joseph Nodule (SMJN) is a metastatic umbilical lesion that occurs as a result of a primary malignancy affecting various organs, with the stomach and colon being the most common in men, and the ovary in women.In this article, we present a case of SMJN in an 82-year-old female patient. An urgent diagnostic workup was conducted, which included an MRI of the abdominal cavity and pelvis. The MRI revealed a large tumor located behind the uterus, along with peritoneal carcinomatosis and the presence of a nodule in the umbilical region. Following a biopsy, the morphological findings and immunohistochemical profile strongly indicated serous carcinoma of ovarian origin. This particular case highlights the challenges encountered in diagnosing SMJN based on physical examination findings, and emphasizes the importance of employing immunohistochemistry to differentiate the primary site of cancer. Gynecological malignancies should always be considered as part of the initial differential diagnosis when dealing with SMJN.

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Section: Discussionmentioning

confidence: 99%

Untitled

2023

IJCMCR

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“…The size can vary between 0.5-15 cm [43][44][45] though it is typically less than 5 cm in diameter. The nodule may appear normal skin coloured, whitish, bluish violet, darkish or brownish red [46] as shown in Figures 1 and 2. The surface of the nodule may appear fissured and ulcerated (Figure 2) and a sanguineous, mucinous, serous, or purulent secretions may also be discharged [47].…”

Section: Clinical Featuresmentioning

confidence: 99%

Sister Mary Joseph Nodule (SMJN) – A Review

Salati

Alsulaim

2023

J. Anal. Oncol.

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Sister Mary Joseph Nodule is an eponymous term referring to an umbilical nodule harbouring malignant metastatic cancer. It is a physical finding that is uncommon yet significant since it indicates the late manifestation of a variety of deep-seated abdominopelvic malignancies. This review article briefly revisits the historical background, epidemiology, anatomical routes of metastasis, clinical presentation, differential diagnosis, diagnostic work-up, clinical significance and prognosis of Sister Mary Joseph’s nodule.

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Sister Mary Joseph nodule in mantle cell lymphoma

Cited by 2 publications

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Sister Mary Joseph Nodule (SMJN) – A Review

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