Sister Mary Joseph’s nodule: an unusual but important physical finding characteristic of widespread internal malignancy

Tso, Simon; Brockley, Julia; Recica, Hilmi; Ilchyshyn, A.

doi:10.3399/bjgp13x673900

Cited by 46 publications

(46 citation statements)

References 3 publications

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Section: Introductionmentioning

confidence: 99%

“…Sister Mary Joseph (SMJ) nodules are rare malignant metastatic umbilical nodules, usually associated with gastrointestinal (50%) or genitourinary (25%) cancers 1. Only 2% of abdomino-pelvic malignancies metastasise to the umbilicus 1. The aetiology of SMJ nodules remains unclear; however, it has been hypothesised that the spread could be due to direct extension, through the lymphatic system or blood vessels 1 2.…”

Section: Introductionmentioning

confidence: 99%

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Sister Mary Joseph nodule: an unusual site for endometrioid cancer metastasis

Petch¹,

Sobota

Saadeh

2019

BMJ Case Rep

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Sister Mary Joseph (SMJ) nodules are rare malignant metastatic umbilical nodules, indicating disseminated disease and associated with a poor prognosis. This is the case of an 80-year-old woman who presented with umbilical discomfort and an ulcerated umbilical nodule. She was noted to have a bulky uterus and vaginal bleeding. CT abdomen-pelvis showed an enlarged uterus and right-sided lymphadenopathy, extending from the groin to the para-aortic area. Upper and lower endoscopies were normal. Biopsy of the umbilical nodule revealed metastatic endometrioid adenocarcinoma grade 1–2 with the endometrium and the ovary suggested as potential primary sites. The patient had cytoreductive surgery including en bloc resection of the umbilical tumour. Final histology confirmed Stage IVb endometrioid adenocarcinoma of the uterus. This unusual case highlights the diagnostic challenges faced with the presentation of an umbilical nodule. Gynaecological malignancy should always be considered within the initial differential diagnosis of an SMJ nodule.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sister Mary Joseph nodule: an unusual site for endometrioid cancer metastasis

Petch¹,

Sobota

Saadeh

2019

BMJ Case Rep

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“…Peri-umbilical metastases are uncommon symptoms of advanced cancers mostly abdominal locations (typically stomach, large bowel, and ovary) [1]. The term is named after Sister Mary Joseph, she was a nurse at Saint Mary's hospital; she recognized that patients with an umbilical lump often died from cancer [2].…”

Section: Introductionmentioning

confidence: 99%

“…The main indication of surgical excision is a solitary metastasis or in case of complications, and have no indication in case of unresectable disseminated cancer. 1 The prognosis is related with the primary tumor, the SMJN caused by ovarian cancer have a better survival rate [18,19].…”

Section: Introductionmentioning

confidence: 99%

An unusual presentation revealing pancreatic carcinoma: Sister Mary Joseph Nodule

Sghir¹,

Jellal²,

Errami³

et al. 2019

Glob J Medical Clin Case Rep

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“…The term is named after Sister Mary Joseph, who was a nurse at Saint Mary’s hospital; she recognized that patients with an umbilical lump often died from cancer. SMJN is estimated to occur in 1–3% of cases of abdominal and pelvic metastases . The primary tumor of SMJN most frequently occurs in the stomach (37.2%), followed by the pancreas (17.7%), ovary (15.1%), colon (11.5%), and gallbladder (6.2%).…”

mentioning

confidence: 99%