Sister Mary Joseph’s nodule as a rare sign of lymphoma

Çetin, Bülent; Benekli, Mustafa; Bulutay, Pınar; Akyürek, Nalân; Cura, E. S.; Coşkun, Uğur; Büyükberber, Süleyman

doi:10.1007/s12185-011-0897-5

Cited by 4 publications

(6 citation statements)

References 9 publications

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“…In men, the gastrointestinal tract and pancreatobiliary tract are the most frequent 25 breast and lymphoma 6. As with the case reported, it is important to highlight that identifying a primary site may be challenging and in some cases, not identified 9…”

Section: Discussionmentioning

confidence: 84%

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Sister Mary Joseph nodule: a diagnostic challenge

Gibson¹,

Thompson

Konamme

et al. 2018

BMJ Case Reports

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We present the case of a 72-year-old woman who presented with, to our knowledge, the largest reported Sister Mary Joseph lesion in the literature. Often associated with a poor prognosis, the patient went on to have a wide local excision of the lesion and has made a full recovery 2 years after the nodule initially developed. Histological examination confirmed the presence of underlying endometrial cancer and the patient subsequently underwent a total hysterectomy and bilateral salpingo-oopherectomy.

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Section: Discussionmentioning

confidence: 84%

“…In men, the gastrointestinal tract and pancreatobiliary tract are the most frequent 25 breast and lymphoma 6…”

Section: Differential Diagnosismentioning

confidence: 99%

Sister Mary Joseph nodule: a diagnostic challenge

Gibson¹,

Thompson

Konamme

et al. 2018

BMJ Case Reports

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“…The few rare cases found in the literature reported umbilical metastasis of systemic lymphomas; in total, 12 cases have been reported ( Table I ). 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 Although it is not possible to draw firm conclusions regarding the outcome of these patients with umbilical lymphomatous deposits, their prognosis is definitely much better than that of their carcinomatous counterparts.…”

Section: Discussionmentioning

confidence: 99%

Mycosis fungoides mimicking a nodule of Sister Mary Joseph

et al. 2022

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“…1 Recently, in vivo diagnostic techniques such as dermoscopy and reflectance confocal microscopy (RCM) offered new morphological details in BCN. [2][3][4] They showed an excellent correlation with the histological presentation first described by Judalewitsch in 1901. 5 Herein, we add some novel cytomorphological details using a new diagnostic tool, named high definition optical coherence tomography (HD-OCT).…”

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confidence: 83%

“…1 The primary origin is usually the gastrointestinal or genital system, but on rare occasions, this pathology originates from lymphoma. [2][3][4] We describe herein a case of diffuse large B-cell lymphoma (DLBCL) infiltrating only in the umbilicus, histologically presenting as epidermotropism, as an atypical histological presentation of B-cell lymphoma.…”

Section: Editormentioning

confidence: 99%

Epidermotropic diffuse large B‐cell lymphoma infiltrating the umbilicus, presenting as Sister Mary Joseph's nodule

Furudate

Fujimura

Ishibashi

et al. 2015

Acad Dermatol Venereol

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EditorSister Mary Joseph's nodule is an umbilical metastatic nodule from an intra-abdominal tumour.1 The primary origin is usually the gastrointestinal or genital system, but on rare occasions, this pathology originates from lymphoma. [2][3][4] We describe herein a case of diffuse large B-cell lymphoma (DLBCL) infiltrating only in the umbilicus, histologically presenting as epidermotropism, as an atypical histological presentation of B-cell lymphoma.A 36-year-old Japanese man consulted with us about a 1-week history of a painful nodule on the umbilicus. He had been treated for DLBCL developing in the pancreas with a regimen of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone). On the first visit, physical examination disclosed an infiltrated, reddish nodule on the umbilicus (Fig. 1a). Computed tomography (CT) of the abdomen revealed significant enlargement of a tumour at the umbilicus (Fig. 1b). A biopsy specimen from the navel revealed atypical large cells densely infiltrating through the dermal papillae to the subcutaneous tissue, and epidermotropism with involvement of the overlying epidermis (Fig. 2a). Immunohistochemical staining revealed that these large cells were positive for CD10 (Fig. 2b), CD20 (Fig. 2c), CD45, CD79a (Fig. 2d), bcl2 and c-myc and negative for CD3, CD5, CD56, bcl6, and multiple myeloma oncogene-1. From the above data, we diagnosed DLBCL on the umbilicus, presenting as Sister Mary Joseph's nodule.Because the histological finding of epidermotropism in B-cell lymphoma is extremely rare, we employed immunohistochemical staining for matrix metalloproteinase (MMP)-2, MMP-9, and E-cadherin to investigate the underlying mechanisms. Immunohistochemical staining revealed a lack of E-cadherin in tumour-infiltrated areas of epidermis (Fig. S1a, Supporting Information). Moreover, lymphoma cells were positive for MMP-9 (Fig. S1c, Supporting Information) and negative for MMP-2 (Fig. S1b, Supporting Information).In this report, we have described a case of DLBCL infiltrating only the umbilicus, presenting as a Sister Mary Joseph's nodule and showing epidermotropism histologically. To inves-

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Sister Mary Joseph’s nodule as a rare sign of lymphoma

Cited by 4 publications

References 9 publications

Sister Mary Joseph nodule: a diagnostic challenge

Sister Mary Joseph nodule: a diagnostic challenge

Mycosis fungoides mimicking a nodule of Sister Mary Joseph

Epidermotropic diffuse large B‐cell lymphoma infiltrating the umbilicus, presenting as Sister Mary Joseph's nodule

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