2013
DOI: 10.3844/ajptsp.2013.107.119
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Sitagliptin Impairs Healing of Experimentally Induced Gastric Ulcers via Inhibition of Inos and Cox-2 Expression

Abstract: Gastric ulcer healing is a complex process that is regulated by several promoting factors including COX-2 and iNOS. Diabetes mellitus is usually associated with delayed gastric ulcer healing. Hence, the current study was designed to investigate the effect of sitagliptin (dipeptidyl peptidase-4 inhibitor) on gastric ulcer healing and expression of iNOS and COX-2 in rat stomach.The study was conducted on 30 rats divided into three equal groups. Group 1 served as normal control group. Gastric ulcer was induced, b… Show more

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“…19 This condition promotes oxidation stress accompanied by the reduction of PG resulting in the COX-2 activation to induce PG production. 20 The process of gastric mucosal damage induced by aspirin needs longer time until the onset. Therefore, the ulcer appeared on the 4 th day after induction.…”
Section: Discussionmentioning
confidence: 99%
“…19 This condition promotes oxidation stress accompanied by the reduction of PG resulting in the COX-2 activation to induce PG production. 20 The process of gastric mucosal damage induced by aspirin needs longer time until the onset. Therefore, the ulcer appeared on the 4 th day after induction.…”
Section: Discussionmentioning
confidence: 99%