Site and Risk Factors of Antisperm Antibodies Production in the Male Population

Marconi, Marcelo; Weidner, W.

doi:10.1007/978-3-319-40788-3_8

Cited by 21 publications

(15 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In present study, it was found in 26.4% of infertile men with positive anti-sperm antibodies and retractable testicles with an OR 2.13 (1.23-3.70) P=0.008, however in the population studied by Sinasi A, it included a prepuber population and there is a high possibility that an indefinite percentage of patients underwent orchidopexy and this is the cause of the appearance of antisperm antibodies. 18,19 In the population studied by Jiang H et al, authors reviewed a history of 48 men with cryptorchidism who underwent orchidopexy at the prepubertal age, finding 6.7% with antisperm antibodies, without being greater than 50%. Therefore, they could not demonstrate a significant level of antisperm antibodies in infertile men with a history of cryptorchidism.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of anti-sperm antibodies, risk factors associated and their impact on spermatobioscopy in infertile men

Cardeña¹,

Rodríguez²,

Treviño³

et al. 2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: The first immunological correlation with male infertility was reported in 1954 by Wilson and Rumke with the identification of anti-sperm antibodies. The prevalence of anti-sperm antibodies in infertile men varies from 9%-36%, the main cause being the loss of the blood-testicular barrier and otherwise the association with chronic inflammation. It has been shown that immune infertility is found in 15% of patients with varicocele.Methods: A transversal comparative study was carried out with 360 infertile men who were tested for anti-sperm antibodies between January 2011 and July 2018. Two groups were integrated; Group 1, infertile men with positive anti-sperm antibodies >50%, group 2, infertile men with negative anti-sperm <50%. Seminogram parameters were evaluated according to the WHO 5th edition and associated risk factors with anti-sperm antibodies.Results: 360 infertile men were evaluated during the study, 42 were excluded because they did not meet the inclusion criteria, the prevalence of anti-sperm antibodies was 14.5%. Group 1; n=46 (14.5%) and group 2, n=272 (85.5%), the clinical characteristics and the hormonal profile were compared at study admission without significant difference. There was a significant decrease in progressive motility in group 1 (38.7±23.8) vs group 2 (50.1±18.9) p=0.03. Analyzing the risk factors, varicocele was found to be significant 23.7%, OR 2.14 (1.27-3.61) p=0.004 as well as retractable testicle 26.4%, OR 2.13 (1.23-3.70) p= 0.008.Conclusions: The affectation of motility was confirmed, which leads to the suspect varicocele and retractable testicle as risk factors.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of anti-sperm antibodies, risk factors associated and their impact on spermatobioscopy in infertile men

Cardeña¹,

Rodríguez²,

Treviño³

et al. 2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Some of its other causative factors include cross-over interaction between antigenic determinants of sperm and bacterial infections and, active immunoregulatory mechanisms [20] . Microbial infection, in particular, includes production of ASAs by sperm as well as microbial antigens [21] , [22] , [23] , [24] , [25] . It is known that ASAs have the tendency to bind to the sperm, thereby affecting sperm function and fertility [26] , [27] , [28] , [29] , [30] .…”

Section: Introductionmentioning

confidence: 99%

Human MOSPD2: A bacterial Lmb mimicked auto-antigen is involved in immune infertility

Parida

2019

Journal of Translational Autoimmunity

View full text Add to dashboard Cite

Autoantibody production is one of the leading factors of immune infertility, an autoimmune disease of the male reproductive system. The potential involvement of MHC-class II derived self-peptides against bacterial proteins in the antisperm antibody (ASA) production has been reported previously. Apparently, Streptococcus agalactiae has been considered as an important pathogen to impart infection-induced infertility in a bacteriospermia associated leukocytospermia (LCS/BS) state. Hence, the present study attempts to confirm S. agalactiae specific Laminin binding protein (Lmb) derived self-peptide (‘ KDSYTKKAKAFKKEA’) namely human Motile Sperm domain-containing protein 2 (MOSPD2) as an auto-antigen in LCS/BS condition. Semen samples were collected from infertile men with LCS/BS (n = 17) and their fertile counterparts (n = 10). Gram-positive bacteria were predominantly identified in the entire 17 LCS samples using culture method followed by 16S rDNA sequencing technique. TLRs 2 and 4 expression used as markers of immune response in spermatozoa and sperm dysfunction were elevated in the LCS/BS spermatozoa as compared to their fertile counterparts. A significant increase in oxidative stress indices i.e., protein carbonylation, lipid peroxidation and acridine orange test (AOT), was also observed in the LCS/BS spermatozoa. Spermatozoa lysate (both auto and heterologous), bacterial lysate (control) and synthesized MOSPD2 self-peptide were used to test their antigenicity against the autoantibodies by rocket immunoelectrophoresis (RIEP) assay. Seminal plasma from LCS/BS patients with S. agalactiae was used as the source of autoantibodies. Spermatozoa and bacteria lysate; and MOSPD2 self-peptide were able to bind autoantibodies in the seminal plasma. Besides, the self-peptide showed a dose dependent increase in the precipitation of antibody. T-cell epitope mapping of 48 Enterococcus faecalis and 91 Staphylococcus aureus surface proteins confirmed MOSPD2 as a global auto-antigen. Thus, augmentation of TLR expression in LCS/BS spermatozoa inferred MOSPD2 to be a putative immunogen. Altogether, these findings will delineate the significance of MOSPD2 auto-antigen in a bacteria derived immune infertility condition.

show abstract

“…The history of testicular trauma including testicular torsion and cure of hernia were found in our study being high risks for positive ASA. In humans, the conditions destroying the blood-testis barrier are an obvious risk factor for ACAS production, as the immune system comes into direct contact with the antigens Open Journal of Obstetrics and Gynecology on the surface of the spermatozoon [48] [49] [50]. Štula I et al [51] found in their study that ASA increased significantly after hernioraphy.…”

Section: Discussionmentioning

confidence: 99%

Anti-Sperm Antibodies: Risk Factors of Positive Serology among Infertile Men Patients in Kisangani-Democratic Republic of Congo

Mike-Antoine¹,

Sihalikyolo²,

Agasa³

et al. 2019

OJOG

View full text Add to dashboard Cite

Introduction: Antisperm antibodies (ASA) prevalence is high in Kisangani. ASA are one of the male factors of infertility that can reduce spermatozoa motility and cervical penetration or prevent acrosomal reaction and even alter embryo development. This study aims to determine the risk factors of ASA positivity among infertile men in Kisangani. Patient and Method: We conducted a case-control study during a period of 2 years in Kisangani on 111 men who consulted for conception and tested for ASA by ELISA. We did a simple pairing that concerned only the type of infertility. For a better balance between the number of cases and controls per stratum to provide better accuracy in the adjusted OR estimate, we performed a 1:1 match. Results: This study showed that businessmen [ORa = 5.0000(1.2452 − 20.0767)] and jobless [ORa = 5.8125(1.1477 − 29.4367)] were at risk of being positive for ASA. Violent blow to testicles [ORa = 6.7391(1.3455 − 33.7545)], cure of hernia [ORa = 4.3478(1.0722 − 17.6299)], Chlamydia infection [ORa = 4.7125(1.3405 − 16.5665)], leucospermia [ORa = 4.1429(1.0406 − 19.7155)]and presence of Staphylococcus aureus ] were associated to positive ASA. Conclusion: This study shows that factors that may lead to risky sexual behavior and physical or infectious trauma are important risk factors for ASA positivity. It is therefore necessary to search for them systematically during male infertility in order to guide the search for ASA.

show abstract

Site and Risk Factors of Antisperm Antibodies Production in the Male Population

Cited by 21 publications

References 75 publications

Prevalence of anti-sperm antibodies, risk factors associated and their impact on spermatobioscopy in infertile men

Prevalence of anti-sperm antibodies, risk factors associated and their impact on spermatobioscopy in infertile men

Human MOSPD2: A bacterial Lmb mimicked auto-antigen is involved in immune infertility

Anti-Sperm Antibodies: Risk Factors of Positive Serology among Infertile Men Patients in Kisangani-Democratic Republic of Congo

Contact Info

Product

Resources

About