RSC Chem. Biol.
 2024
DOI: 10.1039/d4cb00066h
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Site-directed allostery perturbation to probe the negative regulation of hypoxia inducible factor-1α

Vencel L. Petrovicz,
István Pasztuhov,
Tamás A. Martinek
et al.

Abstract: The interaction between the intrinsically disordered transcription factor HIF-1α and the coactivator proteins p300/CBP is essential in the fast response to low oxygenation. The negative feedback regulator, CITED2, switches off...

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