2011
DOI: 10.5210/jur.v5i1.7507
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Site-Directed Mutagenesis of N5-Carboxyaminoimidazole Ribonucleotide Mutase (Class I PurE) in Bacillus anthracis

Abstract: Anthrax, the infection caused by the Gram-positive pathogen Bacillus anthracis (B. anthracis), is fatal if untreated, and some strains of B. anthracis have been found to be resistant to currently available antibiotics. The development of broad spectrum antibiotics is needed to treat the resistive strains. In antibiotic development, we have targeted B. anthracis Class I PurE enzyme (Ba PurE) as a unique and necessary enzyme in the de novo purine biosynthesis pathway, since the inactivation of this gene prevents… Show more

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