2007
DOI: 10.1111/j.1365-2125.2006.02835.x
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Site of deposition and absorption of an inhaled hydrophilic solute

Abstract: AimsTo characterize the absorption kinetics and bioavailability of an inhaled hydrophilic solute deposited at various sites within the airways. MethodsNine healthy nonsmokers received one intravenous, one oropharyngeal and two pulmonary doses of technetium-99 m-labelled diethylene triamine pentaacetic acid ( 99m Tc-DTPA) in an open and crossover fashion. Pulmonary doses were administered as nebulized large and fine droplet-sized aerosols by Pari and UltraVent nebulizers at fairly rapid and slow inhalation flow… Show more

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Cited by 19 publications
(20 citation statements)
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“…As previously shown, after pulmonary administration, two significantly different intrapulmonary deposition patterns of 99m Tc-DTPA were generated with mean PI 1.8 (Pari) and 2.4 (UltraVent) (p = 0.005) (14). The addition of NaTC to 99m Tc-DTPA delivered by Pari was found to decrease the mean PI to 1.3 (p = 0.001) (Table II).…”
Section: Resultsmentioning
confidence: 95%
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“…As previously shown, after pulmonary administration, two significantly different intrapulmonary deposition patterns of 99m Tc-DTPA were generated with mean PI 1.8 (Pari) and 2.4 (UltraVent) (p = 0.005) (14). The addition of NaTC to 99m Tc-DTPA delivered by Pari was found to decrease the mean PI to 1.3 (p = 0.001) (Table II).…”
Section: Resultsmentioning
confidence: 95%
“…Bioavailability of 99m Tc-DTPA was estimated on the basis of urine data for reasons previously described (14). Oral bioavailability (F fe ) of 99m Tc-DTPA administered with or without NaTC was estimated at 3.0 and 3.1%, respectively.…”
Section: Resultsmentioning
confidence: 99%
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“…This might lead to a difference in deposition, which might influence absorption. However, a recent study (31) with technetium 99m-labeled diethylene triamine penta-acetic acid has shown that deposition might not affect absorption as much as previously anticipated, suggesting that other mechanisms might be involved as well.…”
Section: -Mean Free Plasma Insulin Concentration Curves (A) and Gir Cmentioning
confidence: 89%