Site of Origin of Increased Fibrinolytic Activity During Venous Occlusion.

Evaluation of Euglobulin Clot Lysis Time as a Screening Method for Determination of Blood Plasma Fibrinolytic Activity after Venous Occlusion

“…In 1960, Clarke et al (3) observed that the local fibrinolytic acitivity increased after venous occlusion. This finding has been confirmed later by many groups (4)(5)(6)(7)(8). A standard procedure of venous occlusion during 20 min was described by Robertson et al (9).…”

The Effect of Experimental Arterial Occlusion On the Plasminogen Tissue Activator in Rabbits

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Venous occlusion seems to be a potent stimulus to provoke an enhancement of fibrinolytic activity in plasma and in venous endothelium, 2,3,4,5,6,7 In addition Ogston et a1.8 reported on a significantly increased plasminogen activator of the venous blood compared with the arterial blood. Therefore we tried to elucidate the role of tissue activator of the arterial wall in experimental arterial occlusion.

METHODS

Five adult full grown rabbits weighing 2.5 to 3.5 kg were used.

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Low Fibrinolytic Activity of Blood and Vein Walls in Venous Thrombosis

“…During venous occlusion of a limb the fibrinolytic activity of the venous blood distal to the occluding cuff has been found to be increased (Clarke et al 1960, Cliffton et al 1961, Amery et al 1962, Pandolfi et al 1967). These findings have been taken as evidence suggesting that the plasminogen activator is produced in, and released from, the vessel walls and presented to the bloodstream and that this release maintains the fibrinolytic activity in the general circulation (Warren 1964, Fearnley 1965, Holemans & Tysinger 1965.…”