Site‐Selective Ortho/Ipso C−H Difunctionalizations of Arenes using Thianthrene as a Leaving Group
Dorian Dupommier,
Martin Vuagnat,
Javid Rzayev
et al.
Abstract:Site‐selective ortho/ipso C‐H difunctionalizations of aromatic compounds were designed to afford polyfunctionalized arenes including challenging 1,2,3,4‐tetrasubstituted ones (62 examples, up to 97% yields). To ensure the excellent regioselectivity of the process while keeping high efficiency, an original strategy based on a “C‐H thianthenation/Catellani‐type reaction” sequence was developed starting from simple arenes. Non‐prefunctionalized arenes were first regioselectively converted into the corresponding t… Show more
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