Site-selective oral delivery of therapeutic antibodies to the inflamed colon via a folic acid-grafted organic/inorganic hybrid nanocomposite system

Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances

“…Compared to orally administered IFX solution, EFA-AC-IFXNPs effectively alleviated UC in mice. 114 Notably, Kotla et al have introduced inflammation targeted nanocarriers (IT-NCs) for the delivery of CSA to inflamed sites. These nanocarriers, termed CSA/IT-NCs, possess a compact size, anionic surface charge, and mucin-adhesive properties, facilitating adhesion and penetration through the mucosal epithelium in inflamed regions.…”

The utilization of nanotechnology in the female reproductive system and related disorders

“…These composites capitalize on the unique properties of inorganic materials, such as magnetism and optical properties, to achieve targeted drug delivery and controlled release [ 81 ]. Lee et al develop a pH-responsive folic acid-grafted organic/inorganic hybrid nanocomposite system for site-selective oral delivery of therapeutic antibodies [ 82 ]. Furthermore, Aloisi et al provide a comprehensive summary of recent advances in organic-inorganic hybrid nanomaterials within the realm of women's reproductive health [ 83 ].…”

Targeting pathophysiological changes using biomaterials-based drug delivery systems: A key to managing inflammatory bowel disease

“…The oral administration of this nanocomplex showed great accumulation of the nanocomplex as well as the release of infliximab in the injured colon of DSS-induced colitis mice. In addition, pro-inflammatory factors (including IL-6 and TNF-α) were decreased after the oral use of the nanocomplex ( Lee et al, 2022 ).…”