Site-Selective Peptide/Protein Cleavage

Ni, Jizhi; Kanai, Motomu

doi:10.1007/128_2015_652

Cited by 12 publications

(5 citation statements)

References 165 publications

(166 reference statements)

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“…Sites can be divided into three different types: cleavage sites, binding sites, and active sites. A cleavage site is a specific location at the sequence where site-specific proteases cut the protein [15]. When the protease is known, its name is represented by the protease attribute.…”

Section: ) Sitesmentioning

confidence: 99%

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Towards a Shared, Conceptual Model-Based Understanding of Proteins and Their Interactions

Palacio

Pastor

2021

IEEE Access

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Understanding the human genome is a big research challenge. The huge complexity and amount of genome data require extremely effective and efficient data management policies. A first crucial point is to obtain a shared understanding of the domain, which becomes a very hard task considering the number of different genome data sources. To make things more complicated, those data sources deal with different parts of genome-based information: we not only need to understand them well, but also to integrate and intercommunicate all the relevant information. The protein perspective is a good example: rich, wellknown repositories such as UniProt provide a lot of valuable information that it is not easy to interpret and manage when we want to generate useful results. Proteomes and basic information, protein-protein interaction, protein structure, protein processing events, protein function, etc. provide a lot of information is that needs to be conceptually characterized and delimited. To facilitate the essential common understanding of the domain, this paper uses the case of proteins to analyze the data provided by Uniprot in order to make a sound conceptualization work for identifying the relevant domain concepts. A conceptual model of proteins is the result of this conceptualization process, explained in detail in this work. This holistic conceptual model of proteins presented in this paper is the result of achieving a precise ontological commitment. It establishes concepts and their relationships that are significant in order to have a solid basis to efficiently manage relevant genome data related to proteins.

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Section: ) Sitesmentioning

confidence: 99%

“…FIGURE15. Conceptual model that describes the toxic effect that proteins can cause when they are present in a certain dose or concentration.…”

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confidence: 99%

Towards a Shared, Conceptual Model-Based Understanding of Proteins and Their Interactions

Palacio

Pastor

2021

IEEE Access

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“…Chemical transformation of proteins targeting proteinogenic amino acids is a powerful methodology that can append supernatural functions to biocompatible scaffolds, 28,29) or properly truncate/degrade unnecessary domains, 30) with a wide range of possible applications such as biological control, analysis of biological phenomena, creation of biocompatible materials, and new modalities of therapeutics. 31) However, a variety of reaction patterns are still insufficient to chemically transform proteins at will.…”

Section: Chemoselective Protein Modifications Based On Organoradicalsmentioning

confidence: 99%

Development of Highly Chemoselective Oxidative Transformations by Designing Organoradicals

Oisaki

2018

CHEMICAL & PHARMACEUTICAL BULLETIN

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To conduct organic synthesis in the field of pharmaceutical science, methodologies that can easily and quickly supply compounds with high drug-likeness are highly desirable. Based on the original catalyst design concept "Radical-Conjugated Redox Catalysis (RCRC)" established during my research, various C(sp 3)-H functionalizations and protein modifications have been developed, taking advantage of the high reactivity and chemoselectivity of the single-electron transfer process. This review focuses on the eight-year research efforts by my collaborators and me, from conception to results.

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“…27,31 Despite different methods having been disclosed for Tyr-selective cleavage of peptides/proteins over a 60 year timespan, [32][33][34] there is no systematic review that covers this area. 35,36 Hence, to ll this gap, a section of this review will address the latest updates on the selective peptide/protein cleavage at Tyr sites.…”

Section: Introductionmentioning

confidence: 99%

Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues

et al. 2023

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Site-Selective Peptide/Protein Cleavage

Cited by 12 publications

References 165 publications

Towards a Shared, Conceptual Model-Based Understanding of Proteins and Their Interactions

Towards a Shared, Conceptual Model-Based Understanding of Proteins and Their Interactions

Development of Highly Chemoselective Oxidative Transformations by Designing Organoradicals

Recent developments in the cleavage, functionalization, and conjugation of proteins and peptides at tyrosine residues

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