“…With the purpose of facilitating cellular uptake, the KLA peptide can be fused with cell-penetrating moieties or ligands, encapsulated into liposomes, or complexed with polyelectrolytes. 11,12 After internalization into cancer cells, KLA preferentially interacts with the negatively charged mitochondrial membrane, causing disruption in mitochondrial membrane potential and resulting in cell death. 13,14 Besides, the integration of the KLA peptide with nanomaterials with multi-functionalities may offer a unique approach for the design of KLA therapeutic platforms with mitochondria-targeting and multimodal therapeutic activities for synergistic cancer therapy.…”