2011
DOI: 10.1002/chem.201001795
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Site‐Specific DNA‐Programmed Growth of Fluorescent and Functional Silver Nanoclusters

Abstract: Precise organization of metallic nanoclusters on DNA scaffolds holds great interest for nanopatterned materials that may find uses in electronics, sensors, medicine, and many other fields. Herein, we report the site-specific growth of fluorescent silver nanoclusters by using a mismatched double-stranded DNA template. Few-atom, molecular-scale Ag clusters are found to localize at the mismatched site and the metallized DNA retains its integrity. The DNA-encapsulated nanoclusters can be utilized as functional bio… Show more

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Cited by 86 publications
(60 citation statements)
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“…This unique feature was distinct from any other DNA-templated AgNCs system, where the emission peak was red-shifted with increasing excitation wavelength. Previous studies indicated that the appearance of the multiple emissions was due to the presence of multiple species of fluorescent AgNCs containing different number of Ag atoms in DNA-AgNCs solution (13,14,34–36). Therefore, the unchanged emission peak of T1-AgNCs in our system suggested that there might be just one single species of fluorescent AgNCs in the T1-AgNCs solution.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…This unique feature was distinct from any other DNA-templated AgNCs system, where the emission peak was red-shifted with increasing excitation wavelength. Previous studies indicated that the appearance of the multiple emissions was due to the presence of multiple species of fluorescent AgNCs containing different number of Ag atoms in DNA-AgNCs solution (13,14,34–36). Therefore, the unchanged emission peak of T1-AgNCs in our system suggested that there might be just one single species of fluorescent AgNCs in the T1-AgNCs solution.…”
Section: Resultsmentioning
confidence: 99%
“…However, up to this stage, site specificity and homogeneity still remain a big challenge, and these features are critical for the precise organization of metallic nanoparticles into sophisticated nanostructures and their further applications in electronics, sensors, nanomedicine and many other fields. For instance, mismatched double-stranded DNA (dsDNA) or hairpin DNA have been used to create AgNCs by us and others (13,14), in which the mismatched or single-stranded loop region of hairpin DNA could serve as the template. However, the exact binding site remains unknown and the as-prepared AgNCs usually suffer from highly heterogeneity and lack stability against Cl − (15).…”
Section: Introductionmentioning
confidence: 99%
“…Abasic sites can also selectively recognize DNA bases, which was detected based on AgNC formation [44]. Duplex DNA with gaps [45], and mismatches [46] was also studied for AgNC synthesis. Ren and Qu and co-workers reported the formation of AgNCs on triplex DNA [47].…”
mentioning
confidence: 99%
“…We like to mention that also Oemrawsingh et al (2012) and Zheng et al (2003) observed asymmetric fluorescence line shapes for single Ag clusters. Asymmetric line shapes are also observed in bulk experiments in case of size-selected Ag clusters (Schultz and Gwinn 2012;Huang et al 2011;Mbhele et al 2003;Guo et al 2010). …”
Section: Spectroscopic Propertiesmentioning
confidence: 56%