Site-specific drug delivery in the skin for the localized treatment of skin diseases

Chen, Yang; Feng, Xun; Meng, Shengnan

doi:10.1080/17425247.2019.1645119

Cited by 50 publications

(31 citation statements)

References 214 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Topical administration refers to the application of formulations on the superficial area of the skin for the local treatment of diseases or injuries [25]. Site-specific drug delivery can target several skin sites, such as stratum corneum (SC), viable epidermis, dermis, pilosebaceous unit, hypodermis and deeper tissues [26]. The main advantages of this delivery route are patient acceptance; its painless and noninvasive properties; improvement in drug skin bioavailability; better pharmacological and physiological response; and minimum systemic toxicity and drug exposure to non-desired sites [25].…”

Section: Topical Deliverymentioning

confidence: 99%

“…Partitioning and diffusion from the SC to the viable epidermis and/or dermis, where the active ingredient should produce the desired pharmacological effect [29,30]. The passage of drugs into the skin or through the skin involves three potential routes (Figure 1): the transcellular route, which is related to the drug transport through the lipid matrix and corneocytes of the SC; the intercellular route, in which the drug diffuses between the lipid matrix and the corneocytes; and the transappendageal route, in which the drug is transported through the hair follicles, sebaceous glands or sweat glands [26,31].…”

Section: Topical Deliverymentioning

confidence: 99%

See 1 more Smart Citation

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

View full text Add to dashboard Cite

3D printing has been widely used for the personalization of therapies and on-demand production of complex pharmaceutical forms. Recently, 3D printing has been explored as a tool for the development of topical dosage forms and wound dressings. Thus, this review aims to present advances related to the use of 3D printing for the development of pharmaceutical and biomedical products for topical skin applications, covering plain dressing and products for the delivery of active ingredients to the skin. Based on the data acquired, the important growth in the number of publications over the last years confirms its interest. The semisolid extrusion technique has been the most reported one, probably because it allows the use of a broad range of polymers, creating the most diverse therapeutic approaches. 3D printing has been an excellent field for customizing dressings, according to individual needs. Studies discussed here imply the use of metals, nanoparticles, drugs, natural compounds and proteins and peptides for the treatment of wound healing, acne, pain relief, and anti-wrinkle, among others. The confluence of 3D printing and topical applications has undeniable advantages, and we would like to encourage the research groups to explore this field to improve the patient’s life quality, adherence and treatment efficacy.

show abstract

Section: Topical Deliverymentioning

confidence: 99%

Section: Topical Deliverymentioning

confidence: 99%

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Intradermal drug delivery, which is defined as bypassing the outermost layer of the skin, the stratum corneum , by a suitable device and depositing the drug in the underlying viable skin layers, the epidermis and dermis, is an attractive alternative drug delivery approach employed to overcome certain drug administration challenges ( Zhao et al., 2020 ; Larrañeta et al., 2016 ). Indeed, delivering MTX directly to the psoriatic tissue has several advantages include (i) sparing a high proportion of the systemically administered dose ( Du et al., 2019 ), (ii) reducing the unnecessary systemic MTX exposure, thus avoiding/reducing its systemic toxicity and (iii) evading the non-linear pharmacokinetics and the variable bioavailability associated with oral delivery, thus improving drug efficacy ( Prasad and Koul, 2012 ; Chen et al., 2019 ; Gupta et al., 2012 ). Despite these advantages, intradermal delivery of MTX Na into psoriatic tissue faces significant challenges in that MTX Na is a hydrophilic drug (log P = -1.85) and is mostly in the dissociated form at physiological pH.…”

Section: Introductionmentioning

confidence: 99%

Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis

Tekko

Permana

Vora

et al. 2020

European Journal of Pharmaceutical Sciences

133

View full text Add to dashboard Cite

Highlights We developed methotrexate nanocrystals for its localising and sustaining its release in at the application site in the skin. We incorporated the nanocrystals into dissolving microneedles for intradermal delivery. We successfully localised and sustained methotrexate release in the skin compared to conventional oral route. We successfully reduced the systemic methotrexate exposure using our novel approach.

show abstract

“…The dermal-epidermal junction separates the epidermis from the 1-to 2-mmthick dermis. The dermis contains fibroblasts, is rich in collagen and blood vessels, and is therefore conducive to targeted delivery [4,5]. Underneath the dermis is a subcutaneous layer that encloses fibroblasts and adipose cells that are responsible for fat storage [2].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Membrane Depth Determination Techniques for Active Ingredient Skin Penetration Studies Using Microdialysis

Lubda

Zander

Salazar

et al. 2021

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Introduction: The skin is a major physical barrier to the environment, and thus, percutaneous delivery of active ingredients to the dermal target site faces a unique set of hurdles. The efficacy of these active ingredients is governed by their release into the underlying epidermal and dermal tissue, especially when administered topically. Objective: The aim of this study was to understand if different physicochemical properties influence the skin penetration of active ingredients and the depth to which they penetrate into the dermis. Methods: A microdialysis (MD) setup was used to compare the percutaneous penetration in superficial and deep implanted MD membranes in porcine skin. The precise MD membrane depth was determined using histological sectioning paired with microscopy, ultrasound, and a novel computed tomographic approach. Results: In study A, the measured depth of the superficial and deep implanted MD membranes was compared using histological sectioning, ultrasound, and computed tomography. Experimental determination of the depth up to which penetration occurs was found to be crucial to percutaneous penetration studies. In study B, the lipophilic differences of the active ingredients and its influences on the penetration was tested using hydrophilic caffeine and lipophilic LIP1 as model compounds, which have an identical molecular weight with different lipophilic characteristics. It is assumed that the lipophilic characteristics of active ingredients influence their penetration and thus governs the concentration of these molecules reaching their target site. Conclusion: The transdermal penetration of caffeine was found to exceed that of LIP1 through the hydrophilic environment of the dermis. Thus, the findings of this study show that the precise MD dermis localization and the physicochemical properties, such as lipophilicity, influence the penetration rate of active ingredients and lay the foundation for creating optimized transdermal delivery systems.

show abstract

Site-specific drug delivery in the skin for the localized treatment of skin diseases

Cited by 50 publications

References 214 publications

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

3D-Printed Products for Topical Skin Applications: From Personalized Dressings to Drug Delivery

Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis

Comparison of Membrane Depth Determination Techniques for Active Ingredient Skin Penetration Studies Using Microdialysis

Contact Info

Product

Resources

About