1987
DOI: 10.1002/med.2610070104
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Site‐specific drug delivery

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Cited by 75 publications
(36 citation statements)
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“…Nanoparticles (Carmeliet & Jain 2000) PEG modified gelatin nanoparticles loaded with DNA Intracellular trafficking to tumours and nuclear delivery Liposomes (Fischer et al 1999) FA-PEG-DOPE modified liposomes containing DNA Efficient for pH sensitive endosomal DNA delivery HPMA polymer (Folkman 2002) HPMA-(Gly-Phe-Leu-Gly) linker-TNP 470 complex Selective accumulation in tumour vasculature and prevents TNP-470 from crossing blood-brain barrier Liposomes (Friend & Pangburn 1987) Folate conjugated liposomes Efficient delivery of cytotoxic drug to tumours Nanospheres (Fujita et al 1997) Gelatin nanospheres complexed to DNA Efficient vehicle for gene delivery Nanoparticles (Gale & Yancopoulos 1999) RGD-modified nanoparticles Selective localization of drugs in tumours Nanoparticles (Galle & Krammer 1998) Dextran-drug conjugate incorporated in chitosan nanoparticles Efficient vehicles to suppress tumour volume Nanoparticles (Gaur et al 2000) PLGA nanoparticle conjugated with anti-cancer drug High-loading efficiency and comparable activity to official formulations Microspheres (Gillies & Frechet 2004) Alginate microspheres containing naked DNA (Patri et al 2002a;Gillies & Frechet 2004) (Figure 4). Micelles of PLLA-b-PEO polysulfadimethoxine are pH sensitive due to acidic sulfonamide groups and have been reported to be useful anti-cancer agents .…”
Section: Carrier Systems Formulation Remarksmentioning
confidence: 99%
See 1 more Smart Citation
“…Nanoparticles (Carmeliet & Jain 2000) PEG modified gelatin nanoparticles loaded with DNA Intracellular trafficking to tumours and nuclear delivery Liposomes (Fischer et al 1999) FA-PEG-DOPE modified liposomes containing DNA Efficient for pH sensitive endosomal DNA delivery HPMA polymer (Folkman 2002) HPMA-(Gly-Phe-Leu-Gly) linker-TNP 470 complex Selective accumulation in tumour vasculature and prevents TNP-470 from crossing blood-brain barrier Liposomes (Friend & Pangburn 1987) Folate conjugated liposomes Efficient delivery of cytotoxic drug to tumours Nanospheres (Fujita et al 1997) Gelatin nanospheres complexed to DNA Efficient vehicle for gene delivery Nanoparticles (Gale & Yancopoulos 1999) RGD-modified nanoparticles Selective localization of drugs in tumours Nanoparticles (Galle & Krammer 1998) Dextran-drug conjugate incorporated in chitosan nanoparticles Efficient vehicles to suppress tumour volume Nanoparticles (Gaur et al 2000) PLGA nanoparticle conjugated with anti-cancer drug High-loading efficiency and comparable activity to official formulations Microspheres (Gillies & Frechet 2004) Alginate microspheres containing naked DNA (Patri et al 2002a;Gillies & Frechet 2004) (Figure 4). Micelles of PLLA-b-PEO polysulfadimethoxine are pH sensitive due to acidic sulfonamide groups and have been reported to be useful anti-cancer agents .…”
Section: Carrier Systems Formulation Remarksmentioning
confidence: 99%
“…N-(2-Hydroxy propyl) methacrylamide (HPMA) copolymer conjugated to doxorubicin has been shown to reduce cardiotoxicity by 4-5-times due to efficient localization mediated via the EPR effect (Duncan et al 2005). Thus, a drug conjugated to a macromolecule may lead to a far better distribution of the drug (Friend & Pangburn 1987) and EPR provides a passive transport mechanism for the entry of drug into malignant cells (Kaul et al 2003). Macromolecules such as albumins (Lowenthal et al 2005), globulins (Selby 1990) and synthetic polymer accumulate in the tumour tissues because these tissues have a vascular network characterized by both enhanced permeability of the neovasculature and a lack of the lymphatic recovery system (Matsumura & Maeda 1986).…”
Section: Enhanced Permeation and Retention (Epr) Effectmentioning
confidence: 99%
“…(e.g., drugs, radionuclides) have been achieved by From a chemical point of view all these polytheir conjugation to macromolecules. [3][4][5][6] Peptide meric polypeptides are rather similar, but their sideepitopes are attached to proteins or synthetic macromolecular carriers for construction the new generation of synthetic vaccines. [7][8][9] In order to contribute to the rational design of synthetic carrier, we have established structurefunction correlation by the introduction of new groups of branched polypeptides with the general formula poly[Lys-(X i -DL-Ala m )] (XAK) or poly-[Lys-(DL-Ala m -X i )] (AXK), where i õ 1, m Ç 3, and X represent an optically active residue.…”
Section: Introductionmentioning
confidence: 99%
“…Delivery to a preselected intracellular organelle (e.g. lysosomes) is known as third-order targeting (1).…”
Section: Introductionmentioning
confidence: 99%
“…The following factors and requirements are of importance when considering the development of a drug-monoclonal antibody complex or conjugate for drug targeting (1)(2)(3).…”
Section: Introductionmentioning
confidence: 99%