Site-Specific Inhibitors of Gluconeogenesis

Lardy, Henry A.

doi:10.1007/978-3-642-46158-3_33

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Gluconeogenesis1

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1970

1978

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Cited by 7 publications

(1 citation statement)

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“…This view is supported by inhibitor studies. Aminooxyacetic acid and quinolinic acid, potent inhibitors of gluconeogenesis (LARDY 1969) reduced the secretion of extracellular carbohydrates in normal cultures as well as in cultures with alanine added to the salts medium (table 3 and 4), if present during spherulation,…”

Section: Gluconeogenesismentioning

confidence: 99%

Biochemical Events during Spherule Formation of Physarum polycephalum

Hüttermann¹

1973

Berichte der Deutschen Botanischen Gesellschaft

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Section: Gluconeogenesismentioning

confidence: 99%

Biochemical Events during Spherule Formation of Physarum polycephalum

Hüttermann¹

1973

Berichte der Deutschen Botanischen Gesellschaft

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Inhibition of gluconeogenesis in rat renal cortex slices by metabolites of L-tryptophan in vitro

Endou

Reuter

Weber

1975

Naunyn-Schmiedeberg's Arch. Pharmacol.

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The inhibitory effects of metabolites of L-tryptophan on gluconeo-genesis in rat renal cortex has been established. 1. Glucose production was inhibitied by quinolinate in vitro. The inhibition is due to the decreased phosphoenolpyruvate carboxykinase activity. As suggested for purified enzyme systems, quinolinate seems to exert its action in tissue slices by chelating divalent metal ions. The minimum effective extracellular concentration of the inhibitor was 5 X 10(-5) M with pyruvate as a precursor for gluconeo-genesis. 2. The effect of 3-hydroxyanthranilate is stronger (minimal effective concentration 10(-5) M) than that of quinolinate. 3-Hydroxyanthranilate may be effective in its original form and/or as a dimer degrandation product. The compound(s) exert a second effect in addition to blocking the phosphoenolpyruvate carboxykinase. This block is attained by conversion of 3-hydroxyanthranilate to quinolinate. The non-quinolinate mediated effect may be due to a reduced ATP regeneration. 3. It is suggested that kidney cortex responds sensitively to disturbances in ATP metabolism by reduction of glucose synthesis, when it is not the result of blocked formation of phosphoenolpyruvate.

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Steigerung der Tyrosin-Transaminase-Aktivit�t durch Chinolins�ure

Hardeland

1970

Naturwissenschaften

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Site-Specific Inhibitors of Gluconeogenesis

Cited by 7 publications

References 13 publications

Biochemical Events during Spherule Formation of Physarum polycephalum

Biochemical Events during Spherule Formation of Physarum polycephalum

Inhibition of gluconeogenesis in rat renal cortex slices by metabolites of L-tryptophan in vitro

Steigerung der Tyrosin-Transaminase-Aktivit�t durch Chinolins�ure

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