Site-specific intracoronary thrombolysis with urokinase-coated hydrogel balloons: Acute and follow-up studies in 95 patients

Glazier, James J.; Hirst, Jeffrey A.; Kiernan, Francis J.; Fram, Daniel B.; Eldin, Adel M.; Primiano, Charles; Mitchel, Joseph F.; McKay, Raymond G.

doi:10.1002/(sici)1097-0304(199707)41:3<246::aid-ccd4>3.0.co;2-6

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…20 A clinical study suggested that intracoronary thrombolysis can be safely and rapidly achieved by using limited quantities of urokinase delivered directly to the site of intraluminal clot with hydrogel balloons. 21 The rapid loss of drug from the coatings can be problematic if such processes are initiated upon balloon entry into the blood Vascular Medicine 2000; 5: 97-102 stream, thus protective sheaths over the balloon have been applied to limit this source of loss. Hydrogel-coated balloon catheters have also been used for local delivery of vascular endothelial growth factor cDNA to promote angiogenesis in the peripheral arteries of patients with end-stage arteriopathies.…”

Section: Diffusion-drivenmentioning

confidence: 99%

Local drug delivery: an emerging approach in the treatment of restenosis

Ettenson

Edelman

2000

Vasc Med

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Very limited success has been demonstrated with systemic pharmacological treatment to reduce the incidence of restenosis following angioplasty in patients. The lack of success of many of the pharmacotherapeutic agents in reducing the restenosis rates post-angioplasty and following stent implementation is believed to arise from inadequate concentrations of the agents at the lesion site. This has led to the development of various local delivery devices that would ideally deliver and retain adequate amounts of drug to the vessel wall for sufficient periods of time to ensure a therapeutic effect without inducing further injury or compromising blood flow. Local dosing would avoid systemic toxicity, and the use of modified balloon catheters or coated stents might enable percutaneous approaches.

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Section: Diffusion-drivenmentioning

confidence: 99%