Site-specific occurrence of nonmelanoma skin cancers in patients with cutaneous melanoma

Neale, Rachel E.; Forman, David; Murphy, Mary; Whiteman, David C.

doi:10.1038/sj.bjc.6602745

Cited by 12 publications

(7 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eight percent of melanoma patients develop a secondary melanoma within 2 years of their initial diagnosis [ 8 ]. Melanoma patients also have increased risk of developing other NMSC [ 9 ]: 35% of the patients with lentigo maligna melanomas develop another cutaneous malignancy within 5 years [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population

Dubbini¹,

Puddu²,

Salimbeni³

et al. 2021

IJERPH

View full text Add to dashboard Cite

Background: Guidelines recommend limiting melanoma screening in a population with known risk factors, but none indicates methods for efficient recruitment. The purpose of this study is to compare three different methods of recruiting subjects to be screened for melanoma to detect which, if any, is the most efficient. Methods: From 2010 to 2019, subjects were recruited as follows: (1) regular skin examinations (RS), mainly conducted through the Associazione Contro il Melanoma network; (2) occasional melanoma screening (OS), during annual public campaigns; (3) and selective screening (SS), where people were invited to undergo a skin check after filling in a risk evaluation questionnaire, in cases where the assigned outcome was intermediate/high risk. Melanoma risk factors were compared across different screening methods. Generalized Linear Mixed Models were used for multivariable analysis. Results: A total of 2238 subjects (62.7% women) were recruited, median age 44 years (2–85), and 1094 (48.9 %) records were collected through RS, 826 (36.9 %) through OS, and 318 (14.2 %) through SS. A total of 131 suspicious non-melanoma skin cancers were clinically diagnosed, 20 pathologically confirmed, and 2 melanomas detected. SS performed significantly better at selecting subjects with a family history of melanoma and I-II phototypes compared to OS. Conclusions: Prior evaluation of melanoma known risk factors allowed for effective selection of a population to screen at higher risk of developing a melanoma.

show abstract

Section: Introductionmentioning

confidence: 99%

Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population

Dubbini¹,

Puddu²,

Salimbeni³

et al. 2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…Similar to other cancers, BCC has a complex relationship with sunlight, with many lesions developing on areas that are not frequently exposed to the sun, an age-related plateau in incidence, and a significant relationship between recreational exposure and risk [ 35 ]. On the other hand, the incidence of SCC monotonically increases in the presence of sunlight [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

The Burden of Skin Cancers in Saudi Arabia Through 2011-2022

AlOtaibi,

Basfar,

Jawhari

et al. 2023

Cureus

View full text Add to dashboard Cite

Introduction Skin cancers are classified into melanoma and non-melanoma or keratinocyte cancers. No recent data are found about the epidemiology of skin cancers in Saudi Arabia. The current study aims to determine the burden of skin cancer in the last 11 years from 2011 to 2022. Methods Patients who were diagnosed with any type of skin cancer were enrolled in the study. The diagnosis was conducted based on histopathology and immunohistochemistry. Different variables like age, type of cancer, type of lesions, and treatment approach used were measured. Results A total of 91 patients were diagnosed with skin cancers during the study period. The head and neck were the most common sites for skin cancers. Only 4/91 cases reported invasive melanoma. Both squamous cell carcinoma (SCC) (34/91) and basal cell carcinoma (BCC) (28/91) were found to be the most reported skin cancers. Other cancers including mycosis fungoides (MF) (10/91), Kaposi’s sarcoma (6/91), and dermatofibrosarcoma protuberans (DFSP) (5/91) were also detected. The rest of the detected tumors were rarely detected. Aggressive CD4+/CD4+/CD8+ MF was more prevalent than CD3+/CD4+/CD8- MF cancer cases. CD34+ /S100- DFSP cancers were evident in most of the DFSP cases. Human herpes virus 8 was detected in all Kaposi’s sarcoma cases and all of them were HIV-confirmed cases. Surgical treatment was the most frequently used approach to treat skin cancers, followed by phototherapy (9.9%), surgical/radiotherapy (5.5%), surgical/chemotherapy (4.4%), chemotherapy (3.3%), and then chemoradiotherapy immunotherapy (1.1%). Conclusion The incidences of SCC and BCC are relatively high in comparison to other types of skin cancers with the surgical intervention being most frequently used.

show abstract

“…Although there is no standard measure, sun exposure has generally been classified as intermittent or chronic, and its effects can be considered short-term or cumulative. Intermittent sun exposure appears to be the most important risk factor for melanoma [16,17]. Analytical epidemiological studies have shown the role of intermittent exposure to the sun and are shown schematically in the following table (with odds ratios [OR] of 1.6 to 1.7)…”

Section: Sex Menmentioning

confidence: 99%

Cutaneous Malignant Melanomas: Epidemiological, Clinical and Therapeutic Aspects. Experience of the Plastic Surgery Department in Mohammed Vi Hospital of Marrakech- Morocco.

Dhaidah¹,

Sahibi²,

Bhihi³

et al. 2018

IJAR

View full text Add to dashboard Cite

CTLA4 monoclonal antibodies and targeted therapy with inhibitors of BRAF or MEK for melanoma with BRAF mutated, recent studies have shown that the combination of inhibitors of BRAF and inhibitors of MEK may improve the progression-free survival and eventually increase overall survival, the choice of therapy should be individualized in each case depending on various factors such as BRAF mutation status, age, co-morbidities and topography of metastases ,while chemotherapy and radiation therapy can be used to relieve the symptoms without significant impact on patient survival. Preventing melanoma is a real public health problem requires education of the general population on the need for sunscreen and awareness of melanoma and encouraging early diagnosis with the training of health professionals.

show abstract

Site-specific occurrence of nonmelanoma skin cancers in patients with cutaneous melanoma

Cited by 12 publications

References 26 publications

Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population

Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population

The Burden of Skin Cancers in Saudi Arabia Through 2011-2022

Cutaneous Malignant Melanomas: Epidemiological, Clinical and Therapeutic Aspects. Experience of the Plastic Surgery Department in Mohammed Vi Hospital of Marrakech- Morocco.

Contact Info

Product

Resources

About