Site‐specific phosphorylation of villin remodels the actin cytoskeleton to regulate Sendai viral glycoprotein‐mediated membrane fusion

Chandra, Sunandini; Kumar, Manoj; Sharma, Nisha; Sarkar, Debi P.

doi:10.1002/1873-3468.13477

Cited by 4 publications

(2 citation statements)

References 34 publications

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“…Thisunilamellar vesicle is spherical in shape with an average diameter of ~150nm.The main characteristic of the virosomes is the retention of the most useful viral cover of glycoproteins,i.e., Influenza virus haemagglutinin (HA) and neuraminidase (NA) then they are inserted into the Phosphatide bilayer membrane. They are represented by short surface projections with a size of 15nm [27]. Research has found that to attain the desired therapeutic effect, a physical attachment between the target antigen and the virosomal carrier is necessary.…”

Section: Composition Of Different Reconstituted Virosomesmentioning

confidence: 99%

Virosome: A vector in vaccine delivery

Karpe,

Gupta,

Vyas

et al. 2024

BIO Web Conf.

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These days vaccines are considered the best economical and effective technique for preventing and handling bacterial infections, like human papillomavirus (HPV) or meningitis, allergies, autoimmune Relevant Disorders, Microbial Infections, and many more viral diseases. Annually millions of lives are saved from death-causing infections and other relevant disorders with the help of proper immunization with the help of vaccines. But still, many diseases are not yet preventable by vaccines and there is a chance of the improvement of current vaccines with help of many approaches. One of these is a compound known as a virosome, which is produced when pure haemagglutinin and neuraminidase projections of the influenza virus surface are removed from viral envelope and deposited on the exterior of unilamellar liposomes.Studies have shown that in order to attain the desired therapeutic effect, a physical attachment between the target antigen and the virosomal carrier is necessary. A virosome can bind to and “infect” host cells and deliver the antigen directly into the processing pathway which is an Alternatively, the virosome may be phagocytosed by an APC. So Our review gives a novel idea of the vector technology for vaccine delivery, its properties, method of preparation, and importance as well as some applications of different virosomal vaccine discoveries.

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Section: Composition Of Different Reconstituted Virosomesmentioning

confidence: 99%

Virosome: A vector in vaccine delivery

Karpe,

Gupta,

Vyas

et al. 2024

BIO Web Conf.

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show abstract

“…Phosphorylation of tyrosine residues within the villin core promotes actin severing and bundling by three ways. First by decreasing the binding affinity to F actin, second by inhibiting the addition of new actin monomers and finally severing the preexisting actin filaments [90]. This increases the fluidity of the cytoskeleton and affects its mechanical properties enhancing cell motility in cancer.…”

Section: Villinmentioning

confidence: 99%

Cytoskeletal Remodeling in Cancer

Aseervatham

2020

Biology

109

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Successful metastasis depends on cell invasion, migration, host immune escape, extravasation, and angiogenesis. The process of cell invasion and migration relies on the dynamic changes taking place in the cytoskeletal components; actin, tubulin and intermediate filaments. This is possible due to the plasticity of the cytoskeleton and coordinated action of all the three, is crucial for the process of metastasis from the primary site. Changes in cellular architecture by internal clues will affect the cell functions leading to the formation of different protrusions like lamellipodia, filopodia, and invadopodia that help in cell migration eventually leading to metastasis, which is life threatening than the formation of neoplasms. Understanding the signaling mechanisms involved, will give a better insight of the changes during metastasis, which will eventually help targeting proteins for treatment resulting in reduced mortality and longer survival.

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Newcastle disease virus activates diverse signaling pathways via Src to facilitate virus entry into host macrophages

Shi,

Zhao,

Chen

et al. 2024

J Virol

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In general, it is known that the paramyxovirus gains access to host cells through direct penetration at the plasma membrane; however, emerging evidence suggests more complex entry mechanisms for paramyxoviruses. The endocytic entry of Newcastle disease virus (NDV), a representative member of the paramyxovirus family, into multiple types of cells has been recently reported. Herein, we demonstrate the binding of NDV to induce ganglioside-activated Src signaling, which is responsible for the endocytic entry of NDV through caveolae-mediated endocytosis. This process involved Src-dependent activation of the caveolae-associated Cav1 and Dyn2, as well as specific Rho GTPase and downstream effectors, thereby orchestrating the endocytic entry process of NDV. Our findings uncover a novel molecular mechanism of endocytic entry of NDV into host cells and provide novel insight into paramyxovirus mechanisms of entry.

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Site‐specific phosphorylation of villin remodels the actin cytoskeleton to regulate Sendai viral glycoprotein‐mediated membrane fusion

Cited by 4 publications

References 34 publications

Virosome: A vector in vaccine delivery

Virosome: A vector in vaccine delivery

Cytoskeletal Remodeling in Cancer

Newcastle disease virus activates diverse signaling pathways via Src to facilitate virus entry into host macrophages

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