Site-Specific Variation in Familial Cancer as Suggested by Family History, Multiple Primary Cancer, Age at Onset, and Sex Ratio Associated With Upper, Middle, and Lower Third Esophageal and Gastric Cardia Carcinoma

Wen, Di; Wen, Jian Kang; Zou, Wendi; Yang, Yi; Wen, Xiaoduo; Chen, Yuetong; Akazawa, Kohei; Chen, Geng; Shan, Baoen

doi:10.3389/fonc.2020.579379

Cited by 6 publications

(6 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, relying solely on the TNM staging system has obvious limitations, as it lacks important variables such as age, differentiation grade, and other influential factors. Therefore, it is not suitable for individualized analysis 7,8 . Multiple studies have demonstrated that the log odds of positive lymph nodes (LODDS) are superior to the N stage alone in determining lymph node metastasis and providing accurate prognostic assessments for patients with cancer 9,10 .…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is not suitable for individualized analysis. 7 , 8 Multiple studies have demonstrated that the log odds of positive lymph nodes (LODDS) are superior to the N stage alone in determining lymph node metastasis and providing accurate prognostic assessments for patients with cancer. 9 , 10 In line with this, a nomogram is a graphical calculation instrument based on statistical models that can predict the likely outcomes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Establishment and validation of a prognostic nomogram for postoperative patients with gastric cardia adenocarcinoma: A study based on the Surveillance, Epidemiology, and End Results database and a Chinese cohort

Wang

Feng

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

Background: Gastric cardia adenocarcinoma (GCA) is a highly fatal form of cancer in humans. The aim of this study was to extract clinicopathological data of postoperative patients with GCA from the Surveillance, Epidemiology, and End Results database, analyze prognostic risk factors, and build a nomogram. Methods: In this study, the clinical information of 1448 patients with GCA who underwent radical surgery and were diagnosed between 2010 and 2015 was extracted from the SEER database. The patients were then randomly divided into training (n = 1013) and internal validation (n = 435) cohorts at a 7:3 ratio. The study also included an external validation cohort (n = 218) from a Chinese hospital. The study used the Cox and LASSO models to pinpoint the independent risk factors linked to GCA. The prognostic model was constructed according to the results of the multivariate regression analysis. To assess the predictive accuracy of the nomogram, four methods were used: C-index, calibration curve, timedependent ROC curve, and DCA curve. Kaplan-Meier survival curves were also generated to illustrate the differences in cancer-specific survival (CSS) between the groups. Results: The results of the multivariate Cox regression analysis showed that age, grade, race, marital status, T stage, and log odds of positive lymph nodes (LODDS) were independently associated with cancer-specific survival in the training cohort. Both the C-index and AUC values depicted in the nomogram were greater than 0.71. The calibration curve revealed that the nomogram's CSS prediction was consistent with the actual outcomes. The decision curve analysis suggested moderately positive net benefits. Based on the nomogram risk score, significant differences in survival between the high-and low-risk groups were observed. How to cite this article: Wang L, Ge J, Feng L, et al. Establishment and validation of a prognostic nomogram for postoperative patients with gastric cardia adenocarcinoma: A study based on the Surveillance, Epidemiology, and End Results database and a Chinese cohort.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Establishment and validation of a prognostic nomogram for postoperative patients with gastric cardia adenocarcinoma: A study based on the Surveillance, Epidemiology, and End Results database and a Chinese cohort

Wang

Feng

et al. 2023

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…However, the proportion of people who drank was significantly higher in SMPEEC than in SEEC (Table 1). A possible correlation between alcohol consumption and multiple primary esophageal cancers has been reported by Saeki H and Denggui Wen (19,20). These authors reported that excessive smoking and alcohol consumption were risk factors associated with multiple primary carcinomas, and the mechanism of the carcinoma manifestation involved increased sensitivity of genes to the environment.…”

Section: Discussionmentioning

confidence: 82%

Clinicopathological characteristics of synchronous multiple primary early esophageal cancer and risk factors for multiple lesions

Su,

Wei,

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

BackgroundWith the development of endoscopic technology, the detection rate of synchronous multiple primary early esophageal cancer (SMPEEC) is increasing; however, the risk factors remain unclear. We aimed to assess the clinicopathological characteristics of patients with SMPEEC and investigate the risk factors contributing to the development of multiple lesions.MethodsA retrospective cohort study was conducted on 911 consecutive patients who underwent Endoscopic submucosal dissection (ESD) for primary esophageal neoplasms from January 2013 to June 2021. The patients were divided into the SMPEEC group and the solitary early esophageal cancer (SEEC) group. We compared the differences in clinicopathological characteristics between the two groups and investigated the risk factors linked to multiple lesions. Additionally, we investigated the relationship between the main and accessory lesions.ResultsA total of 87 SMPEEC patients were included in this study, and the frequency of synchronous multiple lesions was 9.55% in patients with early esophageal cancer. The lesions in the SMPEEC group were mainly located in the lower segment of the esophagus (46[52.9%]), whereas those in the SEEC group were in the middle segment (412[50.0%]). The pathology type, tumor location, and circumferential rate of lesions were independent risk factors(P<0.05) for SMPEEC by logistic regression analysis. Significant positive correlations were observed between the main and accessory lesions in terms of morphologic type (r=0.632, P=0.000), tumor location(r=0.325, P=0.037), pathologic type (r=0.299, P=0.003), and depth of invasion (r=0.562, P=0.000).ConclusionPathology type, tumor location, and circumferential rate of lesions were identified as independent risk factors for SMEPPC. Understanding these risk factors and the correlation between the main and accessory lesions could significantly improve the detection rate of SMPEEC.

show abstract

“…Upper esophageal LULs had a 9.72‐fold risk of being detected as SDA as compared with those in the lower esophagus in subjects with a family history of ESCC. (ii) Studies have shown that the proportion of ESCC patients with a positive ESCC family history gradually increased from the lower, middle, to upper esophagus, suggesting a higher genetic susceptibility in the upper esophagus 14 . (iii) ESCCs of the upper esophagus have a worse prognosis, 11 suggesting that tumors in different locations of the esophagus have different biological behaviors.…”

Section: Discussionmentioning

confidence: 99%

Lugol‐unstained lesions location in the esophagus affects the detection rate of malignancy: a population‐based study

Qin,

Liu,

Liu

et al. 2023

J of Gastro and Hepatol

View full text Add to dashboard Cite

IntroductionThis study aimed to evaluate the impact of Lugol‐unstained lesion (LUL) location on the detection yield, which may help the endoscopist select targets for biopsy.MethodsWe enrolled 1064 subjects who had LULs at the baseline screening of a population‐based randomized controlled trial. There were 1166 LULs with recorded location and pathologic diagnosis, and these were used for analysis. The detection rate of severe dysplasia and above (SDA) was calculated as the number of LULs identified as SDA divided by the number of LULs biopsied. Logistic regression with a generalized estimating equation was applied to evaluate the association between the location of a given LUL and the risk of the LUL being SDA.ResultsThe detection rate of SDA for LULs located in the lower, middle, and upper esophagus increased from 5.9% and 10.9% to 16.7%. LUL location was significantly associated with having SDA (adjusted odds ratio (OR)upper vs. lower = 2.88, 95% confidential interval (CI) = 1.48–5.60; adjusted ORmiddle vs. lower = 1.63, 95% CI = 0.96–2.76), and the association was stronger in subgroups with a family history of esophageal squamous cell carcinoma (ESCC) (adjusted ORupper vs. lower = 9.72, 95% CI = 2.57–36.69; adjusted ORmiddle vs. lower = 3.76, 95% CI = 0.93–15.21).ConclusionsOur results suggest that more attention should be paid by endoscopists to LULs in the upper and middle esophagus, particularly for individuals with a family history of ESCC.

show abstract

Site-Specific Variation in Familial Cancer as Suggested by Family History, Multiple Primary Cancer, Age at Onset, and Sex Ratio Associated With Upper, Middle, and Lower Third Esophageal and Gastric Cardia Carcinoma

Cited by 6 publications

References 22 publications

Establishment and validation of a prognostic nomogram for postoperative patients with gastric cardia adenocarcinoma: A study based on the Surveillance, Epidemiology, and End Results database and a Chinese cohort

Establishment and validation of a prognostic nomogram for postoperative patients with gastric cardia adenocarcinoma: A study based on the Surveillance, Epidemiology, and End Results database and a Chinese cohort

Clinicopathological characteristics of synchronous multiple primary early esophageal cancer and risk factors for multiple lesions

Lugol‐unstained lesions location in the esophagus affects the detection rate of malignancy: a population‐based study

Contact Info

Product

Resources

About