2004
DOI: 10.1161/01.atv.0000105054.43931.f0
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Site Specificity of Atherosclerosis

Abstract: Abstract-Atherosclerosis is a complex disease process that affects very specific sites of the vasculature. It is recognized that hemodynamic forces are largely responsible for dictating which vascular sites are either susceptible or resistant to developing atherosclerosis. In addition, a number of systemic and local factors also modulate the pathogenesis of the disease. By studying the development of atherosclerosis in mice, investigators have gained insights into the molecular mechanisms of this disease, alth… Show more

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Cited by 511 publications
(249 citation statements)
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“…A decline in blood flow increases the likelihood of fatty plaque build-up leading to the formation of atherosclerotic lesions at arterial bifurcation sites (VanderLaan et al 2004).…”
Section: Sedentary Behaviour and Physical Activity: Impact On Glucosementioning
confidence: 99%
“…A decline in blood flow increases the likelihood of fatty plaque build-up leading to the formation of atherosclerotic lesions at arterial bifurcation sites (VanderLaan et al 2004).…”
Section: Sedentary Behaviour and Physical Activity: Impact On Glucosementioning
confidence: 99%
“…28 In earlier studies we observed that the adventitial tissue of atherosclerotic arteries of apolipoprotein E-deficient (apoE Ϫ/Ϫ ) mice is a major site of T cell accumulation. 29 We now report on systematic studies using cross-sections of the innominate artery where atherosclerotic plaques closely mimic those found at the human carotid bifurcation, 30 and of the subdiaphragmatic portion of the abdominal aorta, a predilection site for aneurysm formation in apoE Ϫ/Ϫ mouse aorta. 31 We used chow-fed mice to avoid excessive hyperlipidemia and studied mice up to 78 weeks to address several questions: Where in the arterial wall do lymphocytes reside?…”
mentioning
confidence: 93%
“…[13][14][15] Atherosclerosis, a disease characterized by the deposition of fatty plaques on the inner walls of arteries, has a predilection for areas of complex geometry in arterial tree and this has been attributed to flow disturbances in such areas. 16 While blood flow in straight parts of large arteries is pulsatile, unidirectional, and laminar, flow near arterial bifurcations often changes its direction and is non-laminar. 17 In contrast, blood flow in the peripheral circulation is continuous due to the compliance and elastic recoil of major arteries.…”
Section: Discussionmentioning
confidence: 99%