Objective. With the constant development of medical technology, the medical-nursing combination mode targeted at elderly chronic diseases has been proposed, and based on this, the study on the nursing mode of elderly chronic diseases under the background of medical-nursing combination was conducted. Methods. Total of 100 elderly patients with chronic diseases who were admitted to our hospital from April 2019 to April 2020 were selected and divided into a control group and an experimental group by lot drawing, with 50 patients in each group. Continuous nursing was conducted to patients in the control group, and continuous nursing combined with comfort nursing was performed to patients in the experimental group, so as to compare their nursing effective rate, satisfaction with nursing, self-care ability at 6 months after nursing, quality of life (QLI) scores, and blood glucose, pressure, and lipid levels at various periods. Results. Compared with the control group, the experimental group obtained significantly improved nursing effective rate, satisfaction with nursing, Exercise of Self-Care Agency (ESCA) scale scores, QLI scores, and lower blood glucose, pressure, and lipid levels at various periods 6 months after nursing, with statistical significance (
P
all < 0.05). Conclusion. Under the context of medical-nursing combination, the continuous nursing intervention combined with comfort nursing intervention is conductive to promote the self-care ability and nursing effect of elderly patients with chronic diseases and obviously improve their quality of life and psychological state.