This article highlights the structural features of the detachable module for the transportation of long cargoes. The choice of profiles for the detachable module was based on the resistance moments of its components. The detachable module was considered a rod structure on four supports. To determine the longitudinal loads acting on the detachable module, mathematical modeling of its longitudinal dynamics was carried out, provided they were placed on a flat car during a shunting impact. The accelerations obtained were used for the calculations of the detachable module. This article presents the results of the strength calculation of the detachable module under asymmetric loading diagrams, i.e., the action of longitudinal and lateral forces on the detachable module structure. The results of the calculations show that the maximum stresses in the structure of the detachable module when it receives longitudinal loads are 7.7% lower than the permissible ones, and when it receives lateral loads, they are 5.8% lower. Thus, the strength of the detachable module is maintained under the loading diagrams considered. This study also included a modal analysis of the detachable module structure. The first natural frequency of oscillations is found to be 20 Hz. Thus, the safety of the detachable module movement in terms of frequency analysis is ensured. This research will help to create recommendations for the design of modern modular vehicles and improve the efficiency of the transport industry.