Hypochromic anemia was present in 17, leukopenia in 14, elevated sedimentation rate in all cases recorded and an elevated serum globulin in 9. The diagnosis is made by summation of the clinical findings; namely, shortness of breath, joint pains, skin rash, fever, pulmonary, cardiac, and renal abnormalities, and by the laboratory findings of hypochromic anemia, albuminuria, increased sedimentation rate, elevated serum albumin, presence of lupus erythematosus cells, and by a positive skin biopsy.