Six-Minute-Walk Test in Idiopathic Pulmonary Fibrosis

Bois, Roland M. du; Weycker, Derek; Albera, Carlo; Bradford, Williamson Z.; Costabel, Ulrich; Kartashov, Alex; Lancaster, Lisa; Noble, Paul W.; Sahn, Steven A.; Szwarcberg, Javier; Thomeer, Michiel; Valeyre, Dominique; King, Talmadge E.

doi:10.1164/rccm.201007-1179oc

Cited by 384 publications

(137 citation statements)

References 39 publications

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“…With our program we achieved improvements beyond the minimal clinically important difference for 6MWD (24-45 m) and SGRQ (5-8 points), as was previously described in IPF patients (fig. 2, 3) [27,31]. These data have important clinical significance and practical implications, since proven and efficient treatments for IPF are limited.…”

Section: Discussionmentioning

confidence: 99%

Exercise Training-Based Pulmonary Rehabilitation Program Is Clinically Beneficial for Idiopathic Pulmonary Fibrosis

Vainshelboim

Oliveira²,

Yehoshua³

et al. 2014

Respiration

146

172

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Background: Idiopathic pulmonary fibrosis (IPF) is a chronic, devastating, interstitial lung disease, with few therapeutic options. IPF is characterized by pulmonary restriction, dyspnea, hypoxemia, exercise intolerance and poor quality of life (QOL). Objectives: We aimed to examine the effect of exercise training (ET) on clinical outcomes in IPF patients. Methods: A randomized controlled study included thirty-two IPF patients (aged 68 ± 8 years) who were allocated either to the ET group (n = 15), participating in a 12-week, twice-weekly 60-min supervised ET-based pulmonary rehabilitation program, or to a control group (n = 17) continuing with regular medical treatment alone. Cardiopulmonary exercise test, 6-min walking distance (6MWD) test, 30-second chair-stand test, pulmonary function tests, dyspnea and QOL were assessed at baseline and at the end of the 12-week intervention. Results: Significant differences were observed between the ET and the control groups in raw mean deltas (Δ = post- - pre-intervention): Δ6MWD, 81 m, p < 0.001; ΔVO₂ peak, 2.6 ml/kg/min, p = 0.002; Δwork rate, 22 W, p < 0.001; Δanaerobic threshold, 3.1 ml/kg/min, p < 0.001, and ΔFVC % predicted, 6%, p = 0.038. Dyspnea, QOL and 30-second chair-stand were also improved significantly following the program. Conclusions: ET improves exercise tolerance, functional capacity, pulmonary function, dyspnea and QOL in patients with IPF, suggesting a short-term treatment efficacy for clinical improvement, and should be considered the standard care for IPF.

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Section: Discussionmentioning

confidence: 99%

Exercise Training-Based Pulmonary Rehabilitation Program Is Clinically Beneficial for Idiopathic Pulmonary Fibrosis

Vainshelboim

Oliveira²,

Yehoshua³

et al. 2014

Respiration

146

172

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“…According to estimates which have applied similar anchor and distribution-based analyses, the MID in COPD has ranged between 25 and 35 m [19,20,36,37] and in interstitial lung disease, the MID is reported to be between 24 and 45 m [18,40,41] (Table 2). To estimate the anchor-based MID, we applied an external criterion which was specific to functional exercise capacity, which has a strong correlation to change in exercise capacity [12], and a similar approach has been applied in some aforementioned studies [18,19].…”

Section: Discussionmentioning

confidence: 99%

Minimal important difference in field walking tests in non-cystic fibrosis bronchiectasis following exercise training

Lee

Hill

Cecins

et al. 2014

Respiratory Medicine

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“…The reliability coefficients for the same measure are likely to vary depending on the clinical context. For example, the 6MWT demonstrates very different ICCs and SEMs for a population undergoing TKA compared to those undergoing cardiac rehabilitation [15][16][17][18].…”

Section: Questions 1 and 2: Identifying And Interpreting A Measured Vmentioning

confidence: 99%

Outcome Measures in Clinical Practice: Five Questions to Consider When Assessing Patient Outcome

Reid

Kho

Stratford

2015

Curr Phys Med Rehabil Rep

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The use of outcome measures (OMs) in clinical practice has become increasingly important, due to the expectations to account for patient outcomes and justify healthcare expenditures. With the ability to assess patients' current status and change over time, OMs can inform clinical decision-making and help clinicians and patients better understand their current function and projected recovery. When assessing outcomes, there are five key considerations for clinicians: confidence in a measured value; the extent to which valid inferences can be drawn from a measured value; the extent to which valid inferences concerning a patient's change status can be made; the patient specific target value; and the ideal reassessment interval. The purpose of this paper is to provide a guide to help clinicians to choose and effectively utilize OMs. We will address the five important application questions to consider, illustrated with clinical examples using the 6-min walk test in different patient populations.

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Six-Minute-Walk Test in Idiopathic Pulmonary Fibrosis

Abstract: The 6MWT is a reliable, valid, and responsive measure of disease status and a valid endpoint for clinical trials in IPF.

Cited by 384 publications

References 39 publications

Exercise Training-Based Pulmonary Rehabilitation Program Is Clinically Beneficial for Idiopathic Pulmonary Fibrosis

Exercise Training-Based Pulmonary Rehabilitation Program Is Clinically Beneficial for Idiopathic Pulmonary Fibrosis

Minimal important difference in field walking tests in non-cystic fibrosis bronchiectasis following exercise training

Outcome Measures in Clinical Practice: Five Questions to Consider When Assessing Patient Outcome

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