Six-Month Physical Activity Versus Sclerostin and Interleukin 6 Concentration in Patients Receiving Renal Replacement Therapy by Hemodialysis – Pilot Study

Abstract

Background: Chronic kidney disease and renal replacement therapy are associated with reduced physical activity, which may result in the presence of mineral-bone disorders and an increase in inflammation markers. The aim of the study was to assess the relationship between the performance of daily physical activity, expressed in the number of steps performed by patients undergoing hemodialysis and the concentration of selected biochemical parameters (SCL, IL-6). Materials and Methods: The study involved 33 patients aged 59.8 ± 9.8 years from the dialysis station at the Department of Nephrology, Transplantology and Internal Medicine PUM. Group C consisted of 30 people aged 54.9 (9.37), with GFR over 60 mL/min/1.73m. The study group was divided into S-N and N-S. Participants of the S-N group were assigned the task of performing the appropriate daily number of steps, and the N-S group was to perform spontaneous physical activity. The tasks were replaced after the third month of the research project. Physical activity was measured with pedometers. Anthropometric and biochemical parameters were assessed at baseline, after the third and sixth month of the study. Descriptive statistics, intergroup comparisons using Mann-Whitney U or Kruskal-Wallis tests and Spearman correlation analysis were performed. The level of significance was set at p≤0.005. Results: Patients from the S-N and N-S groups compared to group C performed significantly fewer steps in the 0-3 month and 4-6 month periods. In the S-N group, with an increase in steps performed in the period of 4-6 months, sclerostin levels dropped in the 6th month. In group C, the concentration of SCL and IL-6 decreased with the increase in the number of steps taken. Only in group C the waist circumference decreased with the increase of the number of steps performed. Conclusions: Patients receiving renal replacement therapy by hemodialysis showed significantly lower physical activity compared to people without kidney disease. Performing bigger number of steps can lower sclerostin levels in hemodialysis patients.

Does Exercising with the Use of Virtual Reality during Haemodialysis Have an Impact on Plasma Levels of Interleukin 1β, Interleukin 6, and Interleukin 8?

“…In the literature, there are reports of numerous benefits which derive from regular physical activity and its enhancement for the health and wellbeing of patients with chronic renal disease [ 10 , 27 , 28 , 29 , 30 ]. Despite the above, this group of patients features significantly lower physical activity levels than people with normal renal function [ 10 , 31 ].…”

“…In the literature, there are reports of numerous benefits which derive from regular physical activity and its enhancement for the health and wellbeing of patients with chronic renal disease [ 10 , 27 , 28 , 29 , 30 ]. Despite the above, this group of patients features significantly lower physical activity levels than people with normal renal function [ 10 , 31 ]. An introduction of physical activity monitoring devices and innovative work out forms may enhance exercise attractiveness and become a motivation option for haemodialysed patients to work out regularly.…”

“…During inflammation, the levels of various cytokines rise, including those of the pleiotropic IL-6, with its gene mapped to chromosome 7p15-p21 [6][7][8]. Already in the early stages of CKD, IL-6 increases, even more so in haemodialysis patients [9,10]. Proinflammatory factors, including IL-1β, affect the levels of IL-8, with its gene mapped to chromosome 4q12-q13 [11].…”