Six-month results of stenting of the femoropopliteal artery and predictive value of interleukin-6: Comparison with high-sensitivity C-reactive protein

Abstract

Objectives To determine the association of pre- and postinterventional serum levels of interleukin-6 and high-sensitivity C-reactive protein at the six-month evaluation of restenosis after stenting of the femoropopliteal artery. Methods Sixty-eight consecutive patients with steno-occlusive femoropopliteal artery disease of Rutherford category III or IV who underwent stent implantation were included. Six-month patency was evaluated with color-coded duplex ultrasound. The association of in-stent restenosis with interleukin-6 and high-sensitivity C-reactive protein levels at baseline, and 24-h postintervention was assessed with a multivariate logistic regression analysis. Results In-stent restenosis was found in 15 patients (22.1%) within six months. Interleukin-6 and high-sensitivity C-reactive protein levels were significantly increased at 24-h postintervention compared to their preintervention values ( p < 0.001 and p = 0.002, respectively). Interleukin-6 values at baseline (odds ratio, 1.11; 95% confidence interval: 1.00, 1.23; p = 0.044) and 24-h postintervention (odds ratio, 1.04; 95% confidence interval: 1.02, 1.06; p < 0.001) were independently associated with six-month in-stent restenosis. Twenty-four-hour postinterventional high-sensitivity C-reactive protein levels were also found to be related to restenosis (odds ratio, 1.15; 95% confidence interval: 1.04, 1.26; p = 0.006), but high-sensitivity C-reactive protein levels at baseline did not show an independent association with in-stent restenosis (odds ratio, 0.57; 95% confidence interval: 0.35, 1.80; p = 0.667). Smoking, diabetes mellitus, and cumulative stent length were other parameters associated with an increased risk for in-stent restenosis. Conclusions Femoropopliteal artery angioplasty with stent placement induces an inflammatory response. Interleukin-6 is a powerful independent predictor of intermediate-term outcomes for stenting of the femoropopliteal artery, suggesting that its predictive value may be superior to that of high-sensitivity C-reactive protein.

[Retracted] Predictive Value of Perioperative Cytokine Levels on the Risk for In‐Stent Restenosis in Acute Myocardial Infarction Patients

“…When the plaque is inflammatory or ruptured, the factor can be released into the blood. Guo et al [ 17 ] evaluated the correlation of in-stent restenosis with IL-6 and serum hs-CRP levels at baseline and 24 hours postoperatively using multivariate logistic regression analysis and believed that IL-6 is a powerful independent predictor for the midterm outcome of femoral artery stent placement, indicating that its predictive value is better than CRP. In this study, IL-6 level was markedly higher in the restenosis group than that in the nonrestenosis group at 3 days postoperatively, and IL-6 is a risk factor for in-stent restenosis.…”

Serum inflammatory factors such as MMP-9 are associated with post-percutaneous transluminal angioplastyacute myocardial infarction in coronary heart disease patients complicated by lower extremity arteriosclerosis obliterans

“…TNF-αcan be a predictor of impaired peak leg blood flow in chronic heart failure patients, as it can reduce the peak leg blood flow (32). While IL-6 has been indicated to be a reliable predictor of 6-month in-stent restenosis after femoral-popliteal artery stenting (33) four Ifs studied in this research with postoperative adverse events in the setting of cardiovascular disease.…”

Multi-Modality Imaging of Atheromatous Plaques in Peripheral Arterial Disease: Integrating Molecular and Imaging Markers

“…Some researchers believe IL-6 is more specific to vascular inflammation than CRP [ 134 ]. Previous studies have found higher IL-6 levels associated with the incidence of PAD and PAD severity [ 135 , 136 , 137 , 138 , 139 ]. Supporting the role of IL-6 in PAD diagnosis and risk stratification, Chen et al found that patients with a higher grade of CT-derived peripheral artery stenosis had higher IL-6 levels than those with lower stenosis grades ( Table 2 ) [ 140 ].…”