Six months versus nine months chemotherapy for tuberculosis of lymph nodes: Final results

Campbell, I. A.; Ormerod, L P; Friend, John; Jenkins, Peter; Prescott, R.

doi:10.1016/s0954-6111(05)80265-3

Cited by 76 publications

(52 citation statements)

References 6 publications

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“…As some concerned comparative studies, there were eight treatment schedules of 6 months' duration and three schedules of 9 months' duration [7±14]. Two articles used the same study population; one reported the preliminary results, the other the final results [10,11]. The total number of patients was 644 (table 1).…”

Section: Resultsmentioning

confidence: 99%

“…During treatment, new nodes or enlargement of existing lymph nodes occurred in 79/468=17% [7,8,10,11,13]. Nodes were present after treatment in 143/423=34% of the patients [7,8,10,11,13].…”

Section: Resultsmentioning

confidence: 99%

“…Nodes were present after treatment in 143/423=34% of the patients [7,8,10,11,13]. The size of the nodes was not reported, or the nodes were not suspected of harbouring disease.…”

Section: Resultsmentioning

confidence: 99%

“…After a mean follow-up of 29 months, nodes were still present in 41/378=11% [7,8,10,11]. However, the number of patients with a relapse on clinical grounds after successful treatment of 6 months' duration was 13/422=3.3% 95% CI 1.7±5.5, mean follow-up 31 months).…”

Section: Resultsmentioning

confidence: 99%

“…In contrast with smear-positive pulmonary tuberculosis, bacteriological confirmation of a cure is not available. However an immunological response to the antigens released from the dead bacilli may be reflected by the development of new nodes, increases in diameter, or complications such as sinus and abscess formation during treatment or follow-up [11].…”

Section: Discussionmentioning

confidence: 99%

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Cervical tuberculous lymphadenitis

Eyselbergs¹,

Snoeckx²,

Beeck³

et al. 2011

Journal of the Belgian Society of Radiology

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The aim of the study was to determine the optimal duration of treatment for patients with tuberculous lymphadenitis.The Medline database was searched for relevant articles published between 1978± 1997. Inclusion criteria were study populations of patients with predominantly cervical tuberculous lymphadenitis in whom the diagnosis had been confirmed bacteriologically and/or histologically, or was made probable by using clinical and laboratory markers. Treatment management had to include at least isoniazid, rifampicin and pyrazinamide and a follow-up of at least 12 months after the end of treatment. Patients with resistance to rifampicin and pyrazinamide and previous treatment for tuberculosis were excluded. The number of patients who relapsed after treatment was calculated.The study population in eight out of the 35 articles retrieved were suitable for analysis. Some concerned comparative studies. There were eight treatment schedules of 6 months' duration and three schedules of 9 months' duration. Treatment for 6 months resulted in a tuberculous lymphadenitis relapse rate of 13/422=3.3% (95% confidence interval: 1.7±5.5), with a mean follow-up of 31 months after completion of treatment. Treatment for 9 months resulted in a relapse rate of 3/112=2.7% (95% confidence interval: 0.6±7.8), with a mean follow-up of 20 months.Despite the limitations of the literature available, 6 months of therapy is probably sufficient for patients with tuberculous lymphadenitis.

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Section: Resultsmentioning

confidence: 99%

“…During treatment, new nodes or enlargement of existing lymph nodes occurred in 79/468=17% [7,8,10,11,13]. Nodes were present after treatment in 143/423=34% of the patients [7,8,10,11,13].…”

Section: Resultsmentioning

confidence: 99%

“…Nodes were present after treatment in 143/423=34% of the patients [7,8,10,11,13]. The size of the nodes was not reported, or the nodes were not suspected of harbouring disease.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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