Six new palladium(II) mixed ligand complexes of 2-, 3-, 4-monosubstituted derivative of pyridine ring with caffeine moiety: Synthesis, spectroscopic, morphological structures, thermal, antimicrobial and anticancer properties

Al-Saif, Foziah A.; Al‐Humaidi, Jehan Y.; Binjawhar, Dalal Nasser; Refat, Moamen S.

doi:10.1016/j.molstruc.2020.128547

Cited by 26 publications

(12 citation statements)

References 20 publications

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“…Al-Saif et al [ 40 ] synthesized six new PdCl 2 -based palladium complexes—one with picolinic acid ( Figure 12 , structure 23), isonicotinic acid ( Figure 12 , structure 24), nicotinamide ( Figure 12 , structure 25), and these complexes with an additional caffeine ligand ( Figure 12 , structures 26–28). In cytotoxicity assays on colorectal adenocarcinoma (Caco-2) and breast cancer (MCF-7) cell lines, each of the synthesized compounds was found to have this activity.…”

Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

“…In cytotoxicity assays on colorectal adenocarcinoma (Caco-2) and breast cancer (MCF-7) cell lines, each of the synthesized compounds was found to have this activity. However, among the six complexes, the most potent activity was demonstrated by the complex with picolinic acid ( Figure 12 , structure 23), which indicates that it may be a potential anticancer compound used against human colorectal adenocarcinoma and breast cancer [ 40 ].…”

Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

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Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that have transition metals at their core have attracted renewed interest from scientists. Researchers are attempting to use chemotherapeutics, such as cisplatin, in combination therapy (i.e., in order to enhance their effectiveness). Moreover, studies are being carried out to modify molecules, by developing them into multinuclear structures, linking different compounds to commonly used drugs, or encapsulating them in nanoparticles to improve pharmacokinetic parameters, and increase the selectivity of these drugs. Therefore, we attempted to organize recent drug findings that contain palladium and platinum atoms in their structures.

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Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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“…The characteristic azomethine ν(CN) imine peak appeared at 1632 cm –1 in L TH , which shifted to a lower frequency in the corresponding M(III) complexes, 1609–1627 cm –1 range, confirming the involvement of imine nitrogen in coordination with metal ions (Figures S14–S19). , Chelation leads to a weakening of the CN bond owing to the inductive effect of the lone electron pair on imine nitrogen being shared with the M(II) center. − In the 2900–3100 cm –1 region, the medium-to-weak bands are assigned to aliphatic and aromatic υ(C–H) stretching vibrations …”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Zinc(II), Cadmium(II), and Palladium(II) Complexes with the Thiophene-Derived Schiff Base Ligand

et al. 2023

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Zn(II), Pd(II), and Cd(II) complexes, [L TH MCl 2 ] (M = Zn, Pd; X = Br, Cl) and [L TH Cd(μ-X)X] n (X = Cl, Br; n = n, 2), supported by the (E)-N 1,N 1-dimethyl-N 2-(thiophen-2-ylmethylene)ethane-1,2-diamine (L TH ) ligand are synthesized and structurally characterized. Density functional theory (DFT) electronic structure calculations and variable-temperature NMR support the presence of two conformers and a dynamic interconversion process of the minor conformer to the major one in solution. It is found that the existence of two relevant complex conformers and their respective ratios in solution depend on the central metal ions and counter ions, either Cl– or Br–. Among the two relevant conformers, a single conformer is crystallized and X-ray diffraction analysis revealed a distorted tetrahedral geometry for Zn(II) complexes, and a distorted square planar and square pyramidal geometry for Pd(II) and Cd(II) complexes, respectively. It is shown that [L TH MCl 2 ]/LiO i Pr (M = Zn, Pd) and [L TH Cd(μ-Cl)Cl] n /LiO i Pr can effectively catalyze the ring-opening polymerization (ROP) reaction of rac-lactide (rac-LA) with 94% conversion within 30 s with [L TH ZnCl 2 ]/LiO i Pr at 0 °C. Overall, hetero-enriched poly(lactic acid)s (PLAs) were provided by these catalytic systems with [L TH ZnCl 2 ]/LiO i Pr producing PLA with higher heterotactic bias (P r up to 0.74 at 0 °C).

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“…Pyridine ring plays a significant role in many biological systems, such as nicotinamide (vitamin B3), iso‐nicotinic acid, picolinic acid, and nicotinic acid. Pyridine derivatives are associated with some important biological activities such as antitumor, antitubercular, fungicidal, anthelmintic, and antibacterial activity (Abdullahi et al, 2021; Al‐Saif et al, 2020; Eryılmaz et al, 2020; N'Guessan et al, 2017; Tahir et al, 2021). Moreover, coumarins are a vast class of natural products widely occurring as secondary plant metabolites (Hu et al, 2020; H. Liu et al, 2018) and exhibited high levels of biological activities, including antimicrobial, antioxidant, insecticidal, anti‐HIV, anticancer, and antibiotic (Peng et al, 2016; Qin et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors

Abusaif

Aboul-Magd

Wassel

et al. 2022

Drug Development Research

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Developing novel antimicrobial agents has become a necessitate due to the increasing rate of microbial resistance to antibiotics. All the newly adamantane derivatives were evaluated for their antimicrobial activities against six MDR clinical pathogenic isolates. The results exhibited that 13 compounds have from potent to good activity. Among those, five derivatives (6, 7, 9, 14a, and 14b) displayed the potent activities against the different isolates tested (MIC < 0.25 µg/ml with bacteria and <8 µg/ml with fungi) compared with Ciprofloxacin (CIP) and Fluconazole (FCA). Additionally, the potent adamantanes showed bactericidal and fungicidal effects based on (MBCs and MFCs) and the time‐kill assay. The most active adamantane derivatives 7 and 14b exhibited a synergistic effect of ΣFIC ≤ 0.5 with CIP and FCA against the bacterial and fungal isolates. Moreover, no antagonistic effect appeared for the tested derivatives. Additionally, the interaction of DNA gyrase and topoisomerase IV enzymes with the compounds 6, 7, 9, 14a, and 14b exhibited potent antimicrobial activity using in vitro biochemical assays and gel‐based DNA‐supercoiling inhibition method. The activity of DNA gyrase and topoisomerase IV enzymes showed inhibitory activity (IC50) of 6.20 µM and 9.40 µM with compound 7 and 10.14 µM and 13.28 µM with compound 14b, respectively. Surprisingly, exposing compound 7 to gamma irradiation sterilized and increased its activity. Finally, the in‐silico analysis predicted that the most active derivatives had good drug‐likeness and safe properties. Besides, molecular docking and quantum chemical studies revealed several important interactions inside the active sites and showed the structural features necessary for activity.

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Six new palladium(II) mixed ligand complexes of 2-, 3-, 4-monosubstituted derivative of pyridine ring with caffeine moiety: Synthesis, spectroscopic, morphological structures, thermal, antimicrobial and anticancer properties

Cited by 26 publications

References 20 publications

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Synthesis and Characterization of Zinc(II), Cadmium(II), and Palladium(II) Complexes with the Thiophene-Derived Schiff Base Ligand

A new exploration toward adamantane derivatives as potential anti‐MDR agents: Design, synthesis, antimicrobial, and radiosterilization activity as potential topoisomerase IV and DNA gyrase inhibitors

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