Six-week inhalation of CdO nanoparticles in mice: The effects on immune response, oxidative stress, antioxidative defense, fibrotic response, and bones

Tulinská, Jana; Mašánová, Vlasta; Líšková, Aurélia; Mikusova, Miroslava Lehotska; Rollerová, Eva; Krivošíková, Zora; Stefíková, K; Uhnáková, Iveta; Ursı́nyová, Monika; Bábíčková, Janka; Bábelová, Andrea; Bušová, Milena; Tóthová, Ľubomíra; Wsólová, Ladislava; Dušinská, Maria; Sojka, Martin; Horváthová, Mira; Aláčová, Radka; Večeřa, Zbyněk; Mikuška, Pavel; Coufalík, Pavel; Křůmal, Kamil; Čapka, Lukáš; Dočekal, Bohumil

doi:10.1016/j.fct.2019.110954

Cited by 14 publications

(14 citation statements)

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“…Volcanic emissions, fossil fuel and biomass combustion, and cigarette smoke are sources of Cd and Pb released as CdO and PbO [55][56][57][58][59]. Experimental studies have shown that inhaled CdO and PbO are more bioavailable than oral Cd and Pb [60][61][62][63]. Typically, potable water is not a source of Cd or Pb, except in cases where significant amounts of Pb plumbing have been used, as occurred in the recent Flint, Michigan, water crisis [64,65].…”

Section: Environmental Sources Of Cadmium and Leadmentioning

confidence: 99%

Cadmium and Lead Exposure, Nephrotoxicity, and Mortality

Satarug

Gobé

Vesey

et al. 2020

Toxics

147

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The present review aims to provide an update on health risks associated with the low-to-moderate levels of environmental cadmium (Cd) and lead (Pb) to which most populations are exposed. Epidemiological studies examining the adverse effects of coexposure to Cd and Pb have shown that Pb may enhance the nephrotoxicity of Cd and vice versa. Herein, the existing tolerable intake levels of Cd and Pb are discussed together with the conventional urinary Cd threshold limit of 5.24 μg/g creatinine. Dietary sources of Cd and Pb and the intake levels reported for average consumers in the U.S., Spain, Korea, Germany and China are summarized. The utility of urine, whole blood, plasma/serum, and erythrocytes to quantify exposure levels of Cd and Pb are discussed. Epidemiological studies that linked one of these measurements to risks of chronic kidney disease (CKD) and mortality from common ailments are reviewed. A Cd intake level of 23.2 μg/day, which is less than half the safe intake stated by the guidelines, may increase the risk of CKD by 73%, and urinary Cd levels one-tenth of the threshold limit, defined by excessive ß2-microglobulin excretion, were associated with increased risk of CKD, mortality from heart disease, cancer of any site and Alzheimer’s disease. These findings indicate that the current tolerable intake of Cd and the conventional urinary Cd threshold limit do not provide adequate health protection. Any excessive Cd excretion is probably indicative of tubular injury. In light of the evolving realization of the interaction between Cd and Pb, actions to minimize environmental exposure to these toxic metals are imperative.

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Section: Environmental Sources Of Cadmium and Leadmentioning

confidence: 99%

Cadmium and Lead Exposure, Nephrotoxicity, and Mortality

Satarug

Gobé

Vesey

et al. 2020

Toxics

147

View full text Add to dashboard Cite

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“…The assay was performed as described elsewhere. 35 In brief, mouse heparinized whole blood was mixed with hydroethidine. Subsequently, fluorescein-labelled Staphylococcus aureus (SA) bacteria were added to each of the test tubes.…”

Section: Methodsmentioning

confidence: 99%

“…The spleen, abdominal lymph nodes, and thymus were placed in complete RPMI 1640 culture medium. Details of the procedure are described in Tulinska et al 35 The following antibodies, all purchased from eBioscience, were used to stain the cells: anti-mouse CD3e PE, anti-mouse CD4 FITC, anti-mouse CD8a PerCP-eFluor® 710, anti-mouse CD19 FITC and anti-mouse CD335 PerCP-eFluor® 710; isotypic controls (IK): Armenian hamster IgG IK PE, rat IgG2a IK FITC, rat IgG2a IK PerCP-eFluor® 710. Concentrations recommended by the manufacturer were applied.…”

Section: Methodsmentioning

confidence: 99%

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Six-week inhalation of lead oxide nanoparticles in mice affects antioxidant defense, immune response, kidneys, intestine and bones

Tulinská

Krivošíková

Líšková

et al. 2022

Environ. Sci.: Nano

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“…It was suggested that human proximal cells were more susceptible than procine cells [45]. in vivo studies: Exposure of female ICR mice to CdONP for 6 weeks by inhalation produced multiorgan effects including renal fibrosis [46]. Experiments performed in our own laboratory by feeding rats (10 mg/ kg b.w.)…”

Section: Cadmium Nanoparticles (Cdnps)mentioning

confidence: 99%