Six-Year Effect of Depressive Symptoms on the Course of Physical Disability in Community-Living Older Adults

Cronin-Stubbs, Diane; Leon, Carlos F. Mendes de; Beckett, Laurel A.; Glynn, Robert J.; Evans, Denis A.

doi:10.1001/archinte.160.20.3074

Cited by 160 publications

(133 citation statements)

References 41 publications

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“…Depressed cynomolgus macaques share many physiological, neurobiological, and behavioral characteristics of human depression, including reduced body mass, hypothalamic-pituitary-adrenal axis perturbations, autonomic dysfunction, increased cardiovascular disease risk, reduced hippocampal volume, altered serotonergic function, decreased activity levels, low ovarian steroid levels, and increased mortality (Shively et al 2008(Shively et al , 2017Willard and Shively 2012;Willard et al 2015;Silverstein-Metzler et al 2017;. In this investigation, we also confirm the susceptibility of depressed monkeys to exhibit functional declines and increased sedentariness as observed clinically at mid to late life (Bromberger and di Scalea 2009;Lenze et al 2005;Cronin-Stubbs et al 2000). Second, the study benefited from measurement of multiple conceptually related but independent outcomes related to function, activity, and sedentariness.…”

Section: Sedentary Behaviorsupporting

confidence: 76%

Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates

et al. 2017

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Depression is the most common mental health problem in aging persons and is a leading risk factor for physical disability, especially in women. Though antidepressant drugs such as serotonin reuptake inhibitors (SSRI) are commonly prescribed, epidemiological evidence reveals mixed effects of long-term antidepressant use on physical function and activity, possibly depending on depressive status. The purpose of this preclinical trial was to determine the relationships of depressive behavior and the potential for an SSRI treatment to modulate walking speed and activity patterns in older adult female cynomolgus monkeys (Macaca fascicularis). We evaluated the effects of depression and a commonly prescribed SSRI, sertraline HCl (20 mg/kg/day p.o.), on (a) walking speed, (b) accelerometry-derived activity (counts) and sedentariness (daytime 60-s sedentary epochs), and (c) observed locomotor and sedentary behaviors (% time) in adult female depressed and nondepressed monkeys (n = 42; 17.2 ± 1.8 years) during an 18 month pretreatment phase and an 18 month treatment phase using a longitudinal, stratified placebo-control study design. Monkeys that were depressed prior to treatment (19/42) subsequently had slower walking speeds (F D [1, 38] = 4.14; p ≤ 0.05) and tended to be more sedentary during the daytime (F D [1, 38] = 3.63; p ≤ 0.06). Sertraline did not affect depressive behaviors, walking speed, accelerometry-derived physical activity or sedentariness, or time observed in total locomotor or sedentary behavior (all p > 0.10). This study provides the first experimental demonstration of relationships between nonhuman primate behavioral depression and walking speed, activity, and sedentariness and provides evidence for a lack of an effect of SSRI treatment on these phenotypes.

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Section: Sedentary Behaviorsupporting

confidence: 76%

Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates

et al. 2017

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“…Von Korff and Simon concluded that chronic pain and depression are inter-related problems with pain contributing to depression and vice versa (Von Korff and Simon, 1996). Several reports have shown that depression is a contributor to disability (Bruce et al, 1994;Penninx et al, 1998Penninx et al, , 1999Cronin-Stubbs et al, 2000) and, though less well-studied, anxiety symptoms have been found to modestly predict worsening disability in the WHAS. The role of analgesics, often underused in management of pain in older adults, has rarely been addressed but may contribute to maintenance of function.…”

Section: Introductionmentioning

confidence: 99%

The pathway from musculoskeletal pain to mobility difficulty in older disabled women

Leveille

Bean

Ngo

et al. 2007

Pain

116

110

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Little is known about the pathway from musculoskeletal pain to mobility difficulty among older persons. We examined potential physical and psychological mediators of the pain-disability relationship in the Women's Health and Aging Study (WHAS), a cohort of women aged ≥65 who had at least mild disability at baseline. Pain was classified according to location and severity (widespread pain; lower extremity pain; other pain; none or mild pain in only one site). Among women without a lot of difficulty in stair climbing (n = 676) or walking (n = 510) at baseline, those who reported widespread pain were more likely than those with none or mild pain to develop a lot of difficulty with mobility during the 3 year follow-up. The likelihood for mobility difficulty was unchanged after adjusting for physical impairments and symptoms of depression and anxiety (walking aOR = 1.85, 95%CI, 1.08-3.17; stair climbing, aOR = 2.68, 95%CI, 1.56-4.62). Lower extremity pain was associated with increased likelihood for difficulty with climbing stairs but not with walking. However, this association was attenuated after adjusting for physical impairments and psychological symptoms (aOR = 1.66, 95%CI, 0.99-2.77). Pain was not associated with increased risk for becoming unable to walk or climb stairs. The findings suggest that pain is a unique domain as a cause of disablement, independent of the usual pathway to disability via physical impairments. Research is needed to better understand the development of pain-related disability in order to determine optimum approaches to prevent and treat mobility disability in older persons with persistent pain.

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“…However, depressive disorders could lead to cognitive difficulties and may predict cognitive dysfunction 19) . Some previous studies have shown a correlation between cognitive dysfunction or depressive symptoms and decline in physical functioning 20) . However, other studies found no relationship between cognitive dysfunction and depressive disorders.…”

Section: Discussionmentioning

confidence: 99%

Effects of Community-Dwelling Older Adults’Demographics and Social, Mental, and Physical Functions on Depressive Disorder

Lee

Han

2013

J Phys Ther Sci

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Abstract. [Purpose] To identify the relationship between depressive disorder prevalence and cognitive and physical functions of community-dwelling older adults.[Methods] The study subjects were 95 adults over the age of 65 residing in J City. Social and demographic characteristics, cognition, balance, walking, and instrumental activities of daily living (IADLs) were evaluated, along with depressive disorder symptoms, and analyzed with logistic regression.[Results] Depressive disorder among senior citizens was related to the death of a spouse, disease status, ability to walk 10 m, and IADLs. [Conclusion] Interventions that employ social and physical therapeutic approaches to enhance locomotion and activities of daily living (ADLs) through the promotion of psycholoical stability might be effective for senior citizens with depressive disorders.

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Six-Year Effect of Depressive Symptoms on the Course of Physical Disability in Community-Living Older Adults

Abstract: Mild depressive symptoms in older persons (those aged > or =65 years) are associated with an increased likelihood of becoming disabled and a decreased chance of recovery, regardless of age, sex, and other factors that contribute to physical disability.

Cited by 160 publications

References 41 publications

Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates

Relationships of depressive behavior and sertraline treatment with walking speed and activity in older female nonhuman primates

The pathway from musculoskeletal pain to mobility difficulty in older disabled women

Effects of Community-Dwelling Older Adults’Demographics and Social, Mental, and Physical Functions on Depressive Disorder

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